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Protein Domain : IPR013040

Name  Coatomer, gamma subunit, appendage, Ig-like subdomain Short Name  Coatomer_gsu_app_Ig-like-sub
Type  Domain Description  Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer []. While clathrin mediates endocytic protein transport, and transport from ER to Golgi, coatomers primarily mediate intra-Golgi transport, as well as the reverse Golgi to ER transport of dilysine-tagged proteins []. For example, the coatomer COP1 (coat protein complex 1) is responsible for reverse transport of recycled proteins from Golgi and pre-Golgi compartments back to the ER, while COPII buds vesicles from the ER to the Golgi []. Coatomers reversibly associate with Golgi (non-clathrin-coated) vesicles to mediate protein transport and for budding from Golgi membranes []. Activated small guanine triphosphatases (GTPases) attract coat proteins to specific membrane export sites, thereby linking coatomers to export cargos. As coat proteins polymerise, vesicles are formed and budded from membrane-bound organelles. Coatomer complexes also influence Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. In mammals, coatomer complexes can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunits. This entry represents a beta-sandwich structural motif found in the appendage domain of the gamma subunit of coatomer complexes. This subdomain has an immunoglobulin-like beta-sandwich fold containing 7 strands in 2 beta-sheets in a Greek key topology []. The appendage domain of the gamma coatomer subunit has a similar overall fold to the appendage domain of clathrin adaptors, and can also share the same motif-based cargo recognition and accessory factor recruitment mechanisms.

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF08752 PFAM IPR013040
G3DSA:2.60.40.1480 GENE3D IPR013040

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR017106 Coatomer gamma subunit Coatomer_gsu Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0005198 structural molecule activity
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0006886 intracellular protein transport
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0016192 vesicle-mediated transport
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0030126 COPI vesicle coat

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0005198 structural molecule activity
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0006886 intracellular protein transport
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0016192 vesicle-mediated transport
Coatomer, gamma subunit, appendage, Ig-like subdomain   GO:0030126 COPI vesicle coat

1 Parent Features

DB identifier Name Short Name Type
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain Coatomer/clathrin_app_Ig-like Domain

18 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085155 Q8I0G5 Drosophila melanogaster
FBpp0297038 I5ANE0 Drosophila pseudoobscura
FBpp0282417 Q29AE5 Drosophila pseudoobscura
FBpp0172613 B4K7Z2 Drosophila mojavensis
FBpp0237503 B4M106 Drosophila virilis
FBpp0255956 B4PNE7 Drosophila yakuba
A8WUZ6_CAEBR A8WUZ6 Caenorhabditis briggsae
K7I3S0_CAEJA K7I3S0 Caenorhabditis japonica
H2W9N4_CAEJA H2W9N4 Caenorhabditis japonica
G0NUQ5_CAEBE G0NUQ5 Caenorhabditis brenneri
G0PIP7_CAEBE G0PIP7 Caenorhabditis brenneri
COPG_CAEEL Q22498 Caenorhabditis elegans
Q2XN02_CAEEL Q2XN02 Caenorhabditis elegans
F5GUA3_CAEEL F5GUA3 Caenorhabditis elegans
COPG_DROME-2 Q8I0G5-2 Drosophila melanogaster
COPG_DROME-3 Q8I0G5-3 Drosophila melanogaster
G4LU37_DROME G4LU37 Drosophila melanogaster
E3MM32_CAERE E3MM32 Caenorhabditis remanei