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Protein Domain : IPR017106

Name  Coatomer gamma subunit Short Name  Coatomer_gsu
Type  Family Description  Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer []. While clathrin mediates endocytic protein transport, and transport from ER to Golgi, coatomers primarily mediate intra-Golgi transport, as well as the reverse Golgi to ER transport of dilysine-tagged proteins []. For example, the coatomer COP1 (coat protein complex 1) is responsible for reverse transport of recycled proteins from Golgi and pre-Golgi compartments back to the ER, while COPII buds vesicles from the ER to the Golgi []. Coatomers reversibly associate with Golgi (non-clathrin-coated) vesicles to mediate protein transport and for budding from Golgi membranes []. Activated small guanine triphosphatases (GTPases) attract coat proteins to specific membrane export sites, thereby linking coatomers to export cargos. As coat proteins polymerise, vesicles are formed and budded from membrane-bound organelles. Coatomer complexes also influence Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. In mammals, coatomer complexes can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunits. This group represents the coatomer gamma subunit.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR011989 Armadillo-like helical ARM-like Domain
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal Clathrin/coatomer_adapt-like_N Domain
IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain Clathrin_a/coatomer_app_sub_C Domain
IPR013040 Coatomer, gamma subunit, appendage, Ig-like subdomain Coatomer_gsu_app_Ig-like-sub Domain

2 Cross References

Source . Name

Subject . Primary Identifier
PIRSF037093 PIRSF IPR017106

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

19 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085155 Q8I0G5 Drosophila melanogaster
FBpp0297038 I5ANE0 Drosophila pseudoobscura
FBpp0282417 Q29AE5 Drosophila pseudoobscura
FBpp0172613 B4K7Z2 Drosophila mojavensis
FBpp0237503 B4M106 Drosophila virilis
FBpp0255956 B4PNE7 Drosophila yakuba
A8WUZ6_CAEBR A8WUZ6 Caenorhabditis briggsae
K7I3S0_CAEJA K7I3S0 Caenorhabditis japonica
K7HGY4_CAEJA K7HGY4 Caenorhabditis japonica
H2W9N4_CAEJA H2W9N4 Caenorhabditis japonica
G0NUQ5_CAEBE G0NUQ5 Caenorhabditis brenneri
G0PIP7_CAEBE G0PIP7 Caenorhabditis brenneri
COPG_CAEEL Q22498 Caenorhabditis elegans
Q2XN02_CAEEL Q2XN02 Caenorhabditis elegans
F5GUA3_CAEEL F5GUA3 Caenorhabditis elegans
COPG_DROME-2 Q8I0G5-2 Drosophila melanogaster
COPG_DROME-3 Q8I0G5-3 Drosophila melanogaster
G4LU37_DROME G4LU37 Drosophila melanogaster
E3MM32_CAERE E3MM32 Caenorhabditis remanei