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Protein Domain : IPR001569

Name  Ribosomal protein L37e Short Name  Ribosomal_L37e
Type  Family Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].A number of eukaryotic and archaeal ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of proteins of 56 to 96 amino-acid residues that share a highly conserved region located in the N-terminal part.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR018267 Ribosomal protein L37e, conserved site Ribosomal_L37e_CS Conserved_site

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10768 PANTHER IPR001569
PF01907 PFAM IPR001569
PD005132 PRODOM IPR001569
MF_00547 HAMAP IPR001569

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L37e   GO:0003735 structural constituent of ribosome
Ribosomal protein L37e   GO:0006412 translation
Ribosomal protein L37e   GO:0005622 intracellular
Ribosomal protein L37e   GO:0005840 ribosome

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L37e   GO:0003735 structural constituent of ribosome
Ribosomal protein L37e   GO:0006412 translation
Ribosomal protein L37e   GO:0005622 intracellular
Ribosomal protein L37e   GO:0005840 ribosome

0 Parent Features

20 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073844 Q9VXX8 Drosophila melanogaster
FBpp0071888 Q9W1U6 Drosophila melanogaster
FBpp0170771 B4L5B0 Drosophila mojavensis
FBpp0230115 B4MAA7 Drosophila virilis
FBpp0256616 B4P932 Drosophila yakuba
FBpp0261078 B4PWB0 Drosophila yakuba
A8XKH0_CAEBR A8XKH0 Caenorhabditis briggsae
A8WX09_CAEBR A8WX09 Caenorhabditis briggsae
H2WLP3_CAEJA H2WLP3 Caenorhabditis japonica
G0M8Q8_CAEBE G0M8Q8 Caenorhabditis brenneri
G0PH15_CAEBE G0PH15 Caenorhabditis brenneri
G0N722_CAEBE G0N722 Caenorhabditis brenneri
RL37_CAEEL P49622 Caenorhabditis elegans
Q8MPV6_CAEEL Q8MPV6 Caenorhabditis elegans
H2KZG3_CAEEL H2KZG3 Caenorhabditis elegans
O62388_CAEEL O62388 Caenorhabditis elegans
Q4V3Y2_DROME Q4V3Y2 Drosophila melanogaster
Q4V414_DROME Q4V414 Drosophila melanogaster
E3MHT3_CAERE E3MHT3 Caenorhabditis remanei
E3LDZ5_CAERE E3LDZ5 Caenorhabditis remanei