modENCODE |  Help |  blog

Protein Domain : IPR017104

Name  Adaptor protein complex AP-2, alpha subunit Short Name  AP2_complex_asu
Type  Family Description  The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. The adaptor protein complex 2 (AP-2) appears to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface.AP-2 is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). It is a component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM, which interacts with RAB11FIP2. The subunits of clathrin-associated adaptor protein complex 2 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes. This group represents an adaptor protein complex AP-2, alpha subunit.

Publication Counts Displayer

0 Child Features

5 Contains

DB identifier Name Short Name Type
IPR011989 Armadillo-like helical ARM-like Domain
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal Clathrin/coatomer_adapt-like_N Domain
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain Clathrin_a/b/g-adaptin_app_Ig Domain
IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain Clathrin_a-adaptin_app_Ig-like Domain
IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain Clathrin_a-adaptin_app_sub_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF037091 PIRSF IPR017104

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Adaptor protein complex AP-2, alpha subunit   GO:0008565 protein transporter activity
Adaptor protein complex AP-2, alpha subunit   GO:0015031 protein transport
Adaptor protein complex AP-2, alpha subunit   GO:0016020 membrane

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Adaptor protein complex AP-2, alpha subunit   GO:0008565 protein transporter activity
Adaptor protein complex AP-2, alpha subunit   GO:0015031 protein transport
Adaptor protein complex AP-2, alpha subunit   GO:0016020 membrane

0 Parent Features

13 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0088945 E8NH12 Drosophila melanogaster
FBpp0088490 P91926 Drosophila melanogaster
FBpp0280380 Q29N38 Drosophila pseudoobscura
FBpp0167254 B4KFJ2 Drosophila mojavensis
FBpp0234164 B4LTK9 Drosophila virilis
FBpp0261149 B4P2D9 Drosophila yakuba
A8XNZ9_CAEBR A8XNZ9 Caenorhabditis briggsae
K7GXM2_CAEJA K7GXM2 Caenorhabditis japonica
K7GXM1_CAEJA K7GXM1 Caenorhabditis japonica
G0MGV3_CAEBE G0MGV3 Caenorhabditis brenneri
Q22601_CAEEL Q22601 Caenorhabditis elegans
AP2A_DROME-2 P91926-2 Drosophila melanogaster
E3MAV5_CAERE E3MAV5 Caenorhabditis remanei