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Protein Domain : IPR000331

Name  Rap GTPase activating protein domain Short Name  Rap_GAP_dom
Type  Domain Description  Rap small G proteins have been implicated in various cellular processes suchas exocytosis, cAMP signalling, cell adhesion and cell proliferation. Rapproteins acts as molecular switches, with an active GTP-bound form and aninactive GDP-bound form []. The inactive GDP bound form is promoted byGTPase-activating proteins (GAPs). GAP proteins specific for Rap contain aconserved region of around 200 amino-acid residues, the RapGAP domain. Thisdomain can accelerate the GTP hydrolysis activity of Rap by five orders ofmagnitude [].Proteins known to contain a Rap-GAP domain include:RAP1 GTPase activating protein (RAP1GAP).Mammalian tuberin protein, the product of a familial tuberous sclerosisgene which, when deleted, causes begnin tumours. It also have a GAPactivity for Rab5 [].Drosophila Gigas protein, an homologue of tuberin involved in regulation ofcell cycle.Mammalian tuberin-like protein TULIP.GTPase-activating protein Spa-1. It functions as a negative regulator forthe activation of Rap1, thereby having a negative effect on cell adhesion[].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF02145 PFAM IPR000331
PS50085 PROFILE IPR000331

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR003913 Tuberin Tuberin Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Rap GTPase activating protein domain   GO:0005096 GTPase activator activity
Rap GTPase activating protein domain   GO:0051056 regulation of small GTPase mediated signal transduction

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Rap GTPase activating protein domain   GO:0005096 GTPase activator activity
Rap GTPase activating protein domain   GO:0051056 regulation of small GTPase mediated signal transduction

0 Parent Features

65 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084441 Q9VB98 Drosophila melanogaster
FBpp0074588 Q9VW83 Drosophila melanogaster
FBpp0113076 B7Z140 Drosophila melanogaster
FBpp0111587 Q8IRL5 Drosophila melanogaster
FBpp0071374 Q9W2X2 Drosophila melanogaster
FBpp0113077 B7Z138 Drosophila melanogaster
FBpp0306873 A8DYW8 Drosophila melanogaster
FBpp0306872 Q59DZ5 Drosophila melanogaster
FBpp0306870 Q9VM00 Drosophila melanogaster
FBpp0306871 Q9VM02 Drosophila melanogaster
FBpp0309313 Q9I7S4 Drosophila melanogaster
FBpp0290357 E1JIZ3 Drosophila melanogaster
FBpp0304936 M9PD17 Drosophila melanogaster
FBpp0283580 Q29AE3 Drosophila pseudoobscura
FBpp0272149 B5DNU4 Drosophila pseudoobscura
FBpp0274936 Q2M0Y0 Drosophila pseudoobscura
FBpp0280180 B5DHY9 Drosophila pseudoobscura
FBpp0160740 B4KV88 Drosophila mojavensis
FBpp0165505 B4L617 Drosophila mojavensis
FBpp0172316 B4KL25 Drosophila mojavensis
FBpp0173514 B4K9M6 Drosophila mojavensis
FBpp0225960 B4LG17 Drosophila virilis
FBpp0237492 B4M134 Drosophila virilis
FBpp0238027 B4LUQ9 Drosophila virilis
FBpp0262050 B4Q201 Drosophila yakuba
FBpp0262849 B4PXG8 Drosophila yakuba
FBpp0263362 B4NZJ6 Drosophila yakuba
FBpp0264656 B4PFT0 Drosophila yakuba
FBpp0267766 B4IUE9 Drosophila yakuba
FBpp0268713 B4PSA9 Drosophila yakuba