modENCODE |  Help |  blog

Protein Domain : IPR016454

Name  Cysteine desulfurase, NifS Short Name  Cysteine_dSase_NifS
Type  Family Description  This group represents a cysteine desulfurase, NifS type. NifS-like proteins are homodimeric and belong to the alpha-family of pyridoxal-5'-phoshate dependent enzymes []which catalyse the reaction: L-cysteine + (enzyme)-cysteine = L-alanine + (enzyme)-S-sulphanylcysteine Cysteine desulfurase proteins play a central role in the delivery of sulphur to a variety of metabolic pathways []. It is involved in the biosynthesis of iron-sulphur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) []. They are present in all organisms (except viruses). In eukaryotes these enzymes occur in mitochondria since this is the primary site for Fe-S cluster assembly [].

Publication Counts Displayer

4 Child Features

DB identifier Name Short Name Type
IPR010240 Cysteine desulfurase Cys_deSase Family
IPR017644 Cysteine desulfurase, DndA Cysteine_desulfurase_DndA Family
IPR017772 Cysteine desulfurase, NifS, bacterial/archaeal Cys_deSase_NifS_bac/arc Family
IPR017773 Cysteine desulfurase, NifS, proteobacteria Cys_deSase_NifS_proteobacteria Family

2 Contains

DB identifier Name Short Name Type
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 PyrdxlP-dep_Trfase_major_sub1 Domain
IPR020578 Aminotransferase class-V pyridoxal-phosphate binding site Aminotrans_V_PyrdxlP_BS Binding_site

1 Cross References

Source . Name

Subject . Primary Identifier
PIRSF005572 PIRSF IPR016454

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

15 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079874 Q9VKD3 Drosophila melanogaster
FBpp0280950 Q29L91 Drosophila pseudoobscura
FBpp0163392 B4KJS4 Drosophila mojavensis
FBpp0231921 B4LQW5 Drosophila virilis
FBpp0263571 B4P1W4 Drosophila yakuba
A8WTX2_CAEBR A8WTX2 Caenorhabditis briggsae
A8XFP6_CAEBR A8XFP6 Caenorhabditis briggsae
H2VNV3_CAEJA H2VNV3 Caenorhabditis japonica
G0NH83_CAEBE G0NH83 Caenorhabditis brenneri
G0MZJ1_CAEBE G0MZJ1 Caenorhabditis brenneri
G0MZJ2_CAEBE G0MZJ2 Caenorhabditis brenneri
Q19434_CAEEL Q19434 Caenorhabditis elegans
O61741_CAEEL O61741 Caenorhabditis elegans
E3LMP4_CAERE E3LMP4 Caenorhabditis remanei
E3LR89_CAERE E3LR89 Caenorhabditis remanei