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Protein Domain : IPR016082

Name  Ribosomal protein L30, ferredoxin-like fold domain Short Name  Ribosomal_L30_ferredoxin-like
Type  Domain Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Ribosomal protein L30 is one of the proteins from the large ribosomal subunit. L30 belongs to a family of ribosomal proteins which, on the basis of sequence similarities [], groups bacteria and archaea L30, yeast mitochondrial L33, and Drosophila melanogaster, Dictyostelium discoideum(Slime mold), fungal and mammalian L7 ribosomal proteins. L30 from bacteria are small proteins of about 60 residues, those from archaea are proteins of about 150 residues, and eukaryotic L7 are proteins of about 250 to 270 residues.This entry represents a domain with a ferredoxin-like fold, with a core structure consisting of core: beta-alpha-beta-alpha-beta. This domain is found in prokaryotic ribosomal protein L30 (short-chain member of the family), as well as in archaeal L30 (L30a) (long-chain member of the family), the later containing an additional C-terminal (sub)domain).It is also found in nucleolar proteins with similarity to large ribosomal subunit L7 proteins. These are constituents of 66S pre-ribosomal particles and play an essential role in processing of precursors to the large ribosomal subunit RNAs [, , ].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR018038 Ribosomal protein L30, conserved site Ribosomal_L30_CS Conserved_site

3 Cross References

Source . Name

Subject . Primary Identifier
PF00327 PFAM IPR016082
G3DSA:3.30.1390.20 GENE3D IPR016082
SSF55129 SSF IPR016082

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR005998 Ribosomal protein L7, eukaryotic Ribosomal_L7_euk Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

22 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070650 Q9W4I3 Drosophila melanogaster
FBpp0079536 P32100 Drosophila melanogaster
FBpp0111950 Q9VKC1 Drosophila melanogaster
FBpp0280290 Q29NI0 Drosophila pseudoobscura
FBpp0283751 Q29G79 Drosophila pseudoobscura
FBpp0285153 Q29NK0 Drosophila pseudoobscura
FBpp0165674 B4L706 Drosophila mojavensis
FBpp0166279 B4KHZ1 Drosophila mojavensis
FBpp0166816 B4KHK1 Drosophila mojavensis
FBpp0230275 B4MA81 Drosophila virilis
FBpp0231731 B4LUH6 Drosophila virilis
FBpp0232361 B4M9C2 Drosophila virilis
FBpp0261366 B4Q037 Drosophila yakuba
FBpp0263576 B4P1X8 Drosophila yakuba
FBpp0263914 B4NZ56 Drosophila yakuba
A8WVQ1_CAEBR A8WVQ1 Caenorhabditis briggsae
H2VJJ4_CAEJA H2VJJ4 Caenorhabditis japonica
G0MNH0_CAEBE G0MNH0 Caenorhabditis brenneri
RL7_CAEEL O01802 Caenorhabditis elegans
Q8SYI9_DROME Q8SYI9 Drosophila melanogaster
Q8SYU2_DROME Q8SYU2 Drosophila melanogaster
E3M3K8_CAERE E3M3K8 Caenorhabditis remanei