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Protein Domain : IPR017868

Name  Filamin/ABP280 repeat-like Short Name  Filamin/ABP280_repeat-like
Type  Repeat Description  The many different actin cross-linking proteins share a common architecture, consisting of a globular actin-binding domain and an extended rod. Whereas their actin-binding domains consist of two calponin homology domains (see ), their rods fall into three families.The rod domain of the family including the Dictyostelium discoideum(Slime mould) gelation factor (ABP120) and human filamin (ABP280) is constructed from tandem repeats of a 100-residue motif that is glycine and proline rich []. The gelation factor's rod contains 6 copies of the repeat, whereas filamin has a rod constructed from 24 repeats. The resolution of the 3D structure of rod repeats from the gelation factor has shown that they consist of a beta-sandwich, formed by two beta-sheets arranged in an immunoglobulin-like fold [, ]. Because conserved residues that form the core of the repeats are preserved in filamin, the repeat structure should be common to the members of the gelation factor/filamin family.The head to tail homodimerisation is crucial to the function of the ABP120 and ABP280 proteins. This interaction involves a small portion at the distal end of the rod domains. For the gelation factor it has been shown that the carboxy-terminal repeat 6 dimerises through a double edge-to-edge extension of the beta-sheet and that repeat 5 contributes to dimerisation to some extent [, , ].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Source . Name

Subject . Primary Identifier
PF00630 PFAM IPR017868
PS50194 PROFILE IPR017868

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

2 Found In

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR014756 Immunoglobulin E-set Ig_E-set Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

109 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0291569 Q9W204 Drosophila melanogaster
FBpp0071830 Q8MME5 Drosophila melanogaster
FBpp0088478 Q9VEN1 Drosophila melanogaster
FBpp0079210 Q9VLR7 Drosophila melanogaster
FBpp0084551 Q9VB59 Drosophila melanogaster
FBpp0073787 Q9NB71 Drosophila melanogaster
FBpp0290588 Q9W205 Drosophila melanogaster
FBpp0288452 B7Z0L2 Drosophila melanogaster
FBpp0288453 Q7KSF4 Drosophila melanogaster
FBpp0288454 A4V310 Drosophila melanogaster
FBpp0303522 M9PE16 Drosophila melanogaster
FBpp0290288 Q9VQ67 Drosophila melanogaster
FBpp0290290 A8DYT2 Drosophila melanogaster
FBpp0290289 A8DYT3 Drosophila melanogaster
FBpp0290591 E1JGS7 Drosophila melanogaster
FBpp0276870 Q291N7 Drosophila pseudoobscura
FBpp0280034 Q29ML5 Drosophila pseudoobscura
FBpp0280807 Q29LN0 Drosophila pseudoobscura
FBpp0282667 B5DYT7 Drosophila pseudoobscura
FBpp0283665 Q29A41 Drosophila pseudoobscura
FBpp0166224 B4KGW7 Drosophila mojavensis
FBpp0167461 B4KIY6 Drosophila mojavensis
FBpp0168445 B4KPA7 Drosophila mojavensis
FBpp0168446 B4KPA6 Drosophila mojavensis
FBpp0168447 B4KPA5 Drosophila mojavensis
FBpp0171517 B4K6K3 Drosophila mojavensis
FBpp0172364 B4KBT2 Drosophila mojavensis
FBpp0172365 B4KBT3 Drosophila mojavensis
FBpp0224866 B4M662 Drosophila virilis
FBpp0224867 B4M663 Drosophila virilis