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Protein Domain : IPR000232

Name  Heat shock factor (HSF)-type, DNA-binding Short Name  HSF_DNA-bd
Type  Domain Description  Heat shock factor (HSF) is a transcriptional activator of heat shock genes[]: it binds specifically to heat shock promoter elements, which arepalindromic sequences rich with repetitive purine and pyrimidine motifs [].Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, butheat shock activation results in relocalisation to the nucleus [].Each HSF monomer contains one C-terminal and three N-terminal leucine zipperrepeats []. Point mutations in these regions result in disruption ofcellular localisation, rendering the protein constitutively nuclear [].Two sequences flanking the N-terminal zippers fit the consensus of a bi-partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus []. The DNA-binding componentof HSF lies to the N terminus of the first NLS region, and is referred toas the HSF domain.

Publication Counts Displayer

0 Child Features

0 Contains

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00447 PFAM IPR000232
PR00056 PRINTS IPR000232
PS00434 PROSITE IPR000232
SM00415 SMART IPR000232

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Heat shock factor (HSF)-type, DNA-binding   GO:0003700 sequence-specific DNA binding transcription factor activity
Heat shock factor (HSF)-type, DNA-binding   GO:0043565 sequence-specific DNA binding
Heat shock factor (HSF)-type, DNA-binding   GO:0006355 regulation of transcription, DNA-templated
Heat shock factor (HSF)-type, DNA-binding   GO:0005634 nucleus

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Heat shock factor (HSF)-type, DNA-binding   GO:0003700 sequence-specific DNA binding transcription factor activity
Heat shock factor (HSF)-type, DNA-binding   GO:0043565 sequence-specific DNA binding
Heat shock factor (HSF)-type, DNA-binding   GO:0006355 regulation of transcription, DNA-templated
Heat shock factor (HSF)-type, DNA-binding   GO:0005634 nucleus

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

17 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085961 P22813 Drosophila melanogaster
FBpp0110264 Q4H2F9 Drosophila melanogaster
FBpp0110266 Q4H2F7 Drosophila melanogaster
FBpp0110265 Q4H2F8 Drosophila melanogaster
FBpp0306102 Q28XQ3 Drosophila pseudoobscura
FBpp0276672 Q290N2 Drosophila pseudoobscura
FBpp0170172 B4KPT6 Drosophila mojavensis
FBpp0235093 B4LKW6 Drosophila virilis
FBpp0258945 B4P4R6 Drosophila yakuba
A8XTY3_CAEBR A8XTY3 Caenorhabditis briggsae
G0NVM9_CAEBE G0NVM9 Caenorhabditis brenneri
G5EFT5_CAEEL G5EFT5 Caenorhabditis elegans
Q6Q4G5_CAEEL Q6Q4G5 Caenorhabditis elegans
Q9XW54_CAEEL Q9XW54 Caenorhabditis elegans
Q18LB3_CAEEL Q18LB3 Caenorhabditis elegans
Q95TH9_DROME Q95TH9 Drosophila melanogaster
E3LNC0_CAERE E3LNC0 Caenorhabditis remanei