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Protein Domain : IPR006630

Name  RNA-binding protein Lupus La Short Name  Lupus_La_RNA-bd
Type  Domain Description  Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome []. In the nucleus, La acts as a RNA polymerase III (RNAP III)transcription factor, while in the cytoplasm, La acts as a translation factor []. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation []. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis []. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [].Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Source . Name

Subject . Primary Identifier
PF05383 PFAM IPR006630
PS50961 PROFILE IPR006630
SM00715 SMART IPR006630

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR002344 Lupus La protein Lupus_La Family

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

59 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0080906 P40796 Drosophila melanogaster
FBpp0072910 Q9I7T7 Drosophila melanogaster
FBpp0086617 A1Z9R1 Drosophila melanogaster
FBpp0290490 Q9W362 Drosophila melanogaster
FBpp0290398 Q9VAW5 Drosophila melanogaster
FBpp0290399 F9W345 Drosophila melanogaster
FBpp0285401 B5DTP5 Drosophila pseudoobscura
FBpp0285390 B5DTN7 Drosophila pseudoobscura
FBpp0285393 B5DTN2 Drosophila pseudoobscura
FBpp0285399 B5DTP0 Drosophila pseudoobscura
FBpp0273787 B5DTJ2 Drosophila pseudoobscura
FBpp0273788 B5DTJ4 Drosophila pseudoobscura
FBpp0276856 Q291K9 Drosophila pseudoobscura
FBpp0283559 B5DWJ1 Drosophila pseudoobscura
FBpp0284399 Q29HX0 Drosophila pseudoobscura
FBpp0285391 B5DTN5 Drosophila pseudoobscura
FBpp0285392 B5DTN3 Drosophila pseudoobscura
FBpp0285400 B5DTP1 Drosophila pseudoobscura
FBpp0286318 Q29E86 Drosophila pseudoobscura
FBpp0287509 Q29KT4 Drosophila pseudoobscura
FBpp0161772 B4KXE0 Drosophila mojavensis
FBpp0163518 B4L8S5 Drosophila mojavensis
FBpp0167107 B4KLF7 Drosophila mojavensis
FBpp0169502 B4KNY5 Drosophila mojavensis
FBpp0174065 B4K8P7 Drosophila mojavensis
FBpp0229875 B4MG26 Drosophila virilis
FBpp0231811 B4LUX1 Drosophila virilis
FBpp0233775 B4M1R5 Drosophila virilis
FBpp0236429 B4LIN8 Drosophila virilis
FBpp0238907 B4LYK3 Drosophila virilis