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Protein Domain : IPR003172

Name  MD-2-related lipid-recognition domain Short Name  ML_dom
Type  Domain Description  The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of E-set Ig domains. This domain is present in proteins from plants, animals and fungi, including the following proteins:Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes [].House-dust mite allergen proteins such as Der f 2 from Dermatophagoides farinaeand Der p 2 from Dermatophagoides pteronyssinus[].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Source . Name

Subject . Primary Identifier
PF02221 PFAM IPR003172
SM00737 SMART IPR003172

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain

53 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085084 Q9VA41 Drosophila melanogaster
FBpp0085083 Q8IMH5 Drosophila melanogaster
FBpp0083933 Q9VCC8 Drosophila melanogaster
FBpp0271877 Q9VH33 Drosophila melanogaster
FBpp0081654 Q9VH31 Drosophila melanogaster
FBpp0081680 Q9VH32 Drosophila melanogaster
FBpp0085085 Q9VA42 Drosophila melanogaster
FBpp0077492 Q9VQ62 Drosophila melanogaster
FBpp0082350 Q9VFN7 Drosophila melanogaster
FBpp0305667 M9PFS9 Drosophila melanogaster
FBpp0282084 Q298W8 Drosophila pseudoobscura
FBpp0283071 Q29CB5 Drosophila pseudoobscura
FBpp0287099 B5DRV9 Drosophila pseudoobscura
FBpp0280804 Q29LN3 Drosophila pseudoobscura
FBpp0282653 Q29B74 Drosophila pseudoobscura
FBpp0282654 Q29B76 Drosophila pseudoobscura
FBpp0283374 Q29B75 Drosophila pseudoobscura
FBpp0284010 Q298J8 Drosophila pseudoobscura
FBpp0159849 B4K9G6 Drosophila mojavensis
FBpp0166500 B4KKW4 Drosophila mojavensis
FBpp0167459 B4KIY2 Drosophila mojavensis
FBpp0172255 B4KDX4 Drosophila mojavensis
FBpp0172353 B4KCF9 Drosophila mojavensis
FBpp0172354 B4KCF7 Drosophila mojavensis
FBpp0173387 B4K7E2 Drosophila mojavensis
FBpp0173663 B4KCF8 Drosophila mojavensis
FBpp0224855 B4M682 Drosophila virilis
FBpp0224854 B4M684 Drosophila virilis
FBpp0225140 B4M683 Drosophila virilis
FBpp0228620 B4MBY5 Drosophila virilis