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Protein Domain : IPR005818

Name  Linker histone H1/H5, domain H15 Short Name  Histone_H1/H5_H15
Type  Domain Description  Histone proteins have central roles in both chromatin organisation (asstructural units of the nucleosome) and gene regulation (as dynamic componentsthat have a direct impact on DNA transcription and replication). EukaryoticDNA wraps around a histone octamer to form a nucleosome, the first order ofcompaction of eukaryotic chromatin. The core histone octamer is composed of acentral H3-H4 tetramer and two flanking H2A-H2B dimers. Each of the corehistone contains a common structural motif, called the histone fold, whichfacilitates the interactions between the individual core histones.In addition to the core histones, there is a "linker histone" called H1 (or H5 in avian species). The linker histones present in all multicellular eukaryotes are the most divergent group of histones, with numerous cell type- and stage-specific variant. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures.Histone H5 performs the same function as histone H1, and replaces H1 in certain cells. The structure of GH5, the globular domain of the linker histone H5 is known [, ]. The fold is similar to the DNA-binding domain of the catabolite gene activator protein, CAP, thus providing a possible model for the binding of GH5 to DNA.The linker histones, which do not contain the histone fold motif, are critical to the higher-order compaction of chromatin, because they bind to internucleosomal DNA and facilitate interactions between individual nucleosomes. In addition, H1 variants have been shown to be involved in the regulation of developmental genes. A common feature of this protein family is a tripartite structure in which a globular (H15) domain of about 80 amino acids is flanked by two less structured N- and C-terminal tails. The H15domain is also characterised by high sequence homology among the family oflinker histones. The highly conserved H15 domain is essential for the bindingof H1 or H5 to the nucleosome. It consists of a three helix bundle (I-III),with a beta-hairpin at the C terminus. There is also a short three-residuestretch between helices I and II that is in the beta-strand conformation.Together with the C-terminal beta-hairpin, this strand forms the third strandof an antiparallel beta-sheet [, , , ].Proteins known to contain a H15 domain are:- Eukaryotic histone H1. The histones H1 constitute a family with many variants, differing in their affinity for chromatin. Several variants aresimultaneously present in a single cell. For example, the nucleatederythrocytes of birds contain both H1 and H5, the latter being an extremevariant of H1.- Eukaryotic MHYST family of histone acetyltransferase. Histoneacetyltransferases transfer an acetyl group from acetyl-CoA to the epsylon-amino group of lysine within the basic NH2-termini of histones, which bindthe acidic phosphates of DNA [].This entry represents the H15 domain.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00538 PFAM IPR005818
PS51504 PROFILE IPR005818
SM00526 SMART IPR005818

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR005819 Histone H5 Histone_H5 Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Linker histone H1/H5, domain H15   GO:0003677 DNA binding
Linker histone H1/H5, domain H15   GO:0006334 nucleosome assembly
Linker histone H1/H5, domain H15   GO:0000786 nucleosome
Linker histone H1/H5, domain H15   GO:0005634 nucleus

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Linker histone H1/H5, domain H15   GO:0003677 DNA binding
Linker histone H1/H5, domain H15   GO:0006334 nucleosome assembly
Linker histone H1/H5, domain H15   GO:0000786 nucleosome
Linker histone H1/H5, domain H15   GO:0005634 nucleus

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

76 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0091054 Q4ABD8 Drosophila melanogaster
FBpp0091089 P02255 Drosophila melanogaster
FBpp0072159 Q9W1A9 Drosophila melanogaster
FBpp0091101 Q4AB54 Drosophila melanogaster
FBpp0091080 Q4AB94 Drosophila melanogaster
FBpp0091050 Q4ABE3 Drosophila melanogaster
FBpp0082428 Q8MSC4 Drosophila melanogaster
FBpp0276014 B5DNJ5 Drosophila pseudoobscura
FBpp0277879 Q28ZY6 Drosophila pseudoobscura
FBpp0272956 B5DKZ4 Drosophila pseudoobscura
FBpp0168082 B4KLV6 Drosophila mojavensis
FBpp0173970 B4K7G8 Drosophila mojavensis
FBpp0238122 B4LWI0 Drosophila virilis
FBpp0234229 B4MH49 Drosophila virilis
FBpp0236315 B4LPD8 Drosophila virilis
FBpp0236980 B4LVM5 Drosophila virilis
FBpp0238107 B4LWH1 Drosophila virilis
FBpp0238126 B4LWI5 Drosophila virilis
FBpp0257930 B4P6H4 Drosophila yakuba
FBpp0259389 B4PAU4 Drosophila yakuba
FBpp0259482 B4IT11 Drosophila yakuba
FBpp0259483 B4IT10 Drosophila yakuba
FBpp0259491 B4IT12 Drosophila yakuba
FBpp0259650 B4IW85 Drosophila yakuba
FBpp0259712 B4IW14 Drosophila yakuba
FBpp0260153 B4IW92 Drosophila yakuba
FBpp0269261 B4PSQ4 Drosophila yakuba
A8Y087_CAEBR A8Y087 Caenorhabditis briggsae
A8WL90_CAEBR A8WL90 Caenorhabditis briggsae
A8X4Q3_CAEBR A8X4Q3 Caenorhabditis briggsae