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Protein Domain : IPR028325

Name  Voltage-gated potassium channel Short Name  VG_K_chnl
Type  Family Description  Potassium channels are the most diverse group of the ion channel family[, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family iscomposed of several functionally distinct isoforms, which can be broadlyseparated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism,channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins orother second messengers []. In eukaryotic cells, K+channelsare involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in themaintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which hasbeen termed the K+selectivity sequence.In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane.However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains.The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK)[]. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.This entry represents the the voltage-gated Kv channel and the KCNQ channel. KCNQ channels differ from other voltage-gated 6 TM helix channels, chiefly in that they possess no tetramerisation domain.
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Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR003968 Potassium channel, voltage dependent, Kv K_chnl_volt-dep_Kv Family
IPR003937 Potassium channel, voltage dependent, KCNQ K_chnl_volt-dep_KCNQ Family

0 Contains

1 Cross References

Identifier
Source . Name
Subject . Primary Identifier
PTHR11537 PANTHER IPR028325

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier
Subject . Name
Subject . Symbol
Ontology Term . Identifier
Ontology Term . Name
Voltage-gated potassium channel   GO:0005249 voltage-gated potassium channel activity
Voltage-gated potassium channel   GO:0006813 potassium ion transport
Voltage-gated potassium channel   GO:0008076 voltage-gated potassium channel complex

3 Ontology Annotations


Subject . Secondary Identifier
Subject . Name
Subject . Symbol
Ontology Term . Identifier
Ontology Term . Name
Voltage-gated potassium channel   GO:0005249 voltage-gated potassium channel activity
Voltage-gated potassium channel   GO:0006813 potassium ion transport
Voltage-gated potassium channel   GO:0008076 voltage-gated potassium channel complex

1 Parent Features

DB identifier Name Short Name Type
IPR003091 Potassium channel K_chnl Family

191 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0088332 Q8SYL2 Drosophila melanogaster
FBpp0088331 P17972 Drosophila melanogaster
FBpp0304848 R9PY39 Drosophila melanogaster
FBpp0300390 A8DYR5 Drosophila melanogaster
FBpp0088601 E1JJQ5 Drosophila melanogaster
FBpp0088599 P08510 Drosophila melanogaster
FBpp0111766 P17971 Drosophila melanogaster
FBpp0305471 M9PFP1 Drosophila melanogaster
FBpp0290658 Q5PXF9 Drosophila melanogaster
FBpp0290659 A1Z856 Drosophila melanogaster
FBpp0289111 B7YZR3 Drosophila melanogaster
FBpp0289110 B7YZR4 Drosophila melanogaster
FBpp0288427 B7Z009 Drosophila melanogaster
FBpp0304493 M9PC22 Drosophila melanogaster
FBpp0304494 M9PEE2 Drosophila melanogaster
FBpp0300519 M9NGK2 Drosophila melanogaster
FBpp0293736 M9PE38 Drosophila melanogaster
FBpp0293739 M9ND32 Drosophila melanogaster
FBpp0293738 M9NFJ6 Drosophila melanogaster
FBpp0293735 M9MRU9 Drosophila melanogaster
FBpp0293733 Q0E8I8 Drosophila melanogaster
FBpp0293737 A8JNI9 Drosophila melanogaster
FBpp0304580 M9PHG6 Drosophila melanogaster
FBpp0304578 M9PJQ4 Drosophila melanogaster
FBpp0306030 M9MRZ7 Drosophila melanogaster
FBpp0286083 Q29DG1 Drosophila pseudoobscura
FBpp0286851 B5DRF9 Drosophila pseudoobscura
FBpp0282128 B5DMV4 Drosophila pseudoobscura
FBpp0276645 B5E0L1 Drosophila pseudoobscura
FBpp0279269 B5DH77 Drosophila pseudoobscura




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