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Protein Domain : IPR003968

Name  Potassium channel, voltage dependent, Kv Short Name  K_chnl_volt-dep_Kv
Type  Family Description  The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic TM domains with a P-domain between the fifth and sixth, which partially resides in the membrane. The fourth TM domain has positively charged residues at every third residue and acts as a voltage sensor, which triggers the conformational change that opens the channel pore in response to a displacement in membrane potential []. More recently, 4 new electrically-silent alpha subunits have been cloned: Kv5 (KCNF), Kv6 (KCNG), Kv8 and Kv9 (KCNS). These subunits do not themselves possess any functional activity, but appear to form heteromeric channels with Kv2 subunits, and thus modulate Shab channel activity []. When highly expressed, they inhibit channel activity, but at lower levels show more specific modulatory actions.This entry represents the entire Kv family of voltage-dependent potassium channels.

Publication Counts Displayer

7 Child Features

DB identifier Name Short Name Type
IPR003971 Potassium channel, voltage dependent, Kv9 K_chnl_volt-dep_Kv9 Family
IPR003974 Potassium channel, voltage dependent, Kv3 K_chnl_volt-dep_Kv3 Family
IPR003975 Potassium channel, voltage dependent, Kv4 K_chnl_volt-dep_Kv4 Family
IPR003972 Potassium channel, voltage dependent, Kv1 K_chnl_volt-dep_Kv1 Family
IPR003973 Potassium channel, voltage dependent, Kv2 K_chnl_volt-dep_Kv2 Family
IPR003969 Potassium channel, voltage dependent, Kv6 K_chnl_volt-dep_Kv6 Family
IPR003970 Potassium channel, voltage dependent, Kv8.1 K_chnl_volt-dep_Kv8.1 Family

2 Contains

DB identifier Name Short Name Type
IPR003131 Potassium channel tetramerisation-type BTB domain T1-type_BTB Domain
IPR005821 Ion transport domain Ion_trans_dom Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR01491 PRINTS IPR003968

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Potassium channel, voltage dependent, Kv   GO:0005249 voltage-gated potassium channel activity
Potassium channel, voltage dependent, Kv   GO:0006813 potassium ion transport
Potassium channel, voltage dependent, Kv   GO:0008076 voltage-gated potassium channel complex

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Potassium channel, voltage dependent, Kv   GO:0005249 voltage-gated potassium channel activity
Potassium channel, voltage dependent, Kv   GO:0006813 potassium ion transport
Potassium channel, voltage dependent, Kv   GO:0008076 voltage-gated potassium channel complex

1 Parent Features

DB identifier Name Short Name Type
IPR028325 Voltage-gated potassium channel VG_K_chnl Family

138 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0088332 Q8SYL2 Drosophila melanogaster
FBpp0088331 P17972 Drosophila melanogaster
FBpp0304848 R9PY39 Drosophila melanogaster
FBpp0300390 A8DYR5 Drosophila melanogaster
FBpp0088599 P08510 Drosophila melanogaster
FBpp0111766 P17971 Drosophila melanogaster
FBpp0305471 M9PFP1 Drosophila melanogaster
FBpp0288427 B7Z009 Drosophila melanogaster
FBpp0304493 M9PC22 Drosophila melanogaster
FBpp0304494 M9PEE2 Drosophila melanogaster
FBpp0293736 M9PE38 Drosophila melanogaster
FBpp0293739 M9ND32 Drosophila melanogaster
FBpp0293738 M9NFJ6 Drosophila melanogaster
FBpp0293735 M9MRU9 Drosophila melanogaster
FBpp0293733 Q0E8I8 Drosophila melanogaster
FBpp0293737 A8JNI9 Drosophila melanogaster
FBpp0304580 M9PHG6 Drosophila melanogaster
FBpp0306030 M9MRZ7 Drosophila melanogaster
FBpp0286083 Q29DG1 Drosophila pseudoobscura
FBpp0282128 B5DMV4 Drosophila pseudoobscura
FBpp0279269 B5DH77 Drosophila pseudoobscura
FBpp0279974 Q29MF1 Drosophila pseudoobscura
FBpp0160621 B4KX09 Drosophila mojavensis
FBpp0159386 B4KIP8 Drosophila mojavensis
FBpp0162733 B4KZC6 Drosophila mojavensis
FBpp0165151 B4L2A7 Drosophila mojavensis
FBpp0173125 B4KJY6 Drosophila mojavensis
FBpp0226294 B4LCL8 Drosophila virilis
FBpp0228016 B4LE37 Drosophila virilis
FBpp0231256 B4M6S3 Drosophila virilis