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Protein Domain : IPR022671

Name  Ribosomal protein L2, conserved site Short Name  Ribosomal_L2_CS
Type  Conserved_site Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Ribosomal protein L2 is one of the proteins from the large ribosomal subunit. This entry represents the best conserved region located in the C-terminal section of these proteins.In Escherichia coli, L2 is known to bind to the 23S rRNA and to have peptidyltransferase activity. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [, ], groups:Eubacterial L2.Algal and plant chloroplast L2.Cyanelle L2.Archaebacterial L2.Plant L2.Slime mold L2.Marchantia polymorphamitochondrial L2.Paramecium tetraureliamitochondrial L2.Fission yeast K5, K37 and KD4.Yeast YL6.Vertebrate L8.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00467 PROSITE IPR022671

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR008991 Translation protein SH3-like domain Translation_prot_SH3-like Domain
IPR002171 Ribosomal protein L2 Ribosomal_L2 Family
IPR022669 Ribosomal protein L2, C-terminal Ribosomal_L2_C Domain
IPR014726 Ribosomal protein L2, domain 3 Ribosomal_L2_dom3 Domain
IPR005880 Ribosomal protein L2, bacterial/organellar-type Ribosomal_L2_bac/org-type Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L2, conserved site   GO:0003735 structural constituent of ribosome
Ribosomal protein L2, conserved site   GO:0006412 translation
Ribosomal protein L2, conserved site   GO:0005840 ribosome

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L2, conserved site   GO:0003735 structural constituent of ribosome
Ribosomal protein L2, conserved site   GO:0006412 translation
Ribosomal protein L2, conserved site   GO:0005840 ribosome

0 Parent Features

10 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0072801 Q9V3G1 Drosophila melanogaster
FBpp0276477 Q29FA8 Drosophila pseudoobscura
FBpp0161689 B4KYM8 Drosophila mojavensis
FBpp0226791 B4LDV0 Drosophila virilis
FBpp0265334 B4PDD9 Drosophila yakuba
A8X079_CAEBR A8X079 Caenorhabditis briggsae
H2WHF6_CAEJA H2WHF6 Caenorhabditis japonica
G0N0L7_CAEBE G0N0L7 Caenorhabditis brenneri
RL8_CAEEL Q9XVF7 Caenorhabditis elegans
E3MF85_CAERE E3MF85 Caenorhabditis remanei