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Protein Domain : IPR001209

Name  Ribosomal protein S14 Short Name  Ribosomal_S14
Type  Family Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].S14 is one of the proteins from the small ribosomal subunit.In Escherichia coli, S14 is known to be required for the assembly of 30S particlesand may also be responsible for determining the conformation of 16S rRNA at the A site.It belongs to a family of ribosomal proteins [, ]thatinclude, bacterial, algal and plant chloroplast, yeast mitochondrial, cyanelle and archael, Methanococcus vannieliiS14's, as well as yeast mitochondrial MRP2,yeast YS29A/B and mammalian S29.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR023676 Ribosomal protein S14, type Z, archaeal Ribosomal_S14_type-Z_arc Family
IPR023053 Ribosomal protein S14, type Z Ribosomal_S14_Z Family
IPR023036 Ribosomal protein S14, bacterial/plastid Ribosomal_S14_bac/plaastid Family

1 Contains

DB identifier Name Short Name Type
IPR018271 Ribosomal protein S14, conserved site Ribosomal_S14_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR19836 PANTHER IPR001209
PF00253 PFAM IPR001209

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S14   GO:0003735 structural constituent of ribosome
Ribosomal protein S14   GO:0006412 translation
Ribosomal protein S14   GO:0005622 intracellular
Ribosomal protein S14   GO:0005840 ribosome

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S14   GO:0003735 structural constituent of ribosome
Ribosomal protein S14   GO:0006412 translation
Ribosomal protein S14   GO:0005622 intracellular
Ribosomal protein S14   GO:0005840 ribosome

0 Parent Features

20 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081614 Q9VH69 Drosophila melanogaster
FBpp0074554 Q9VWI3 Drosophila melanogaster
FBpp0272856 B5DL77 Drosophila pseudoobscura
FBpp0282154 Q299H9 Drosophila pseudoobscura
FBpp0165305 B4L6X2 Drosophila mojavensis
FBpp0171958 B4K990 Drosophila mojavensis
FBpp0230153 B4MA46 Drosophila virilis
FBpp0237160 B4LYX4 Drosophila virilis
FBpp0262399 B4PZI4 Drosophila yakuba
A8XLG8_CAEBR A8XLG8 Caenorhabditis briggsae
A8XXB7_CAEBR A8XXB7 Caenorhabditis briggsae
H2VV95_CAEJA H2VV95 Caenorhabditis japonica
B3VAC4_CAEBE B3VAC4 Caenorhabditis brenneri
G0P9I1_CAEBE G0P9I1 Caenorhabditis brenneri
G0N3Y4_CAEBE G0N3Y4 Caenorhabditis brenneri
RT14_CAEEL P49391 Caenorhabditis elegans
P90983_CAEEL P90983 Caenorhabditis elegans
Q8IH91_DROME Q8IH91 Drosophila melanogaster
E3ML83_CAERE E3ML83 Caenorhabditis remanei
E3NLH0_CAERE E3NLH0 Caenorhabditis remanei