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Protein Domain : IPR017400

Name  Elongation factor 2 kinase Short Name  Elongation_factor_2_kinase
Type  Family Description  This entry represents elongation factor 2 kinase (eEF-2 kinase), a highly specific kinase that phosphorylates and inactivates eukaryotic elongation factor-2 (eEF-2), and thus can modulate the rate of polypeptide chain elongation during translation. eEF-2 kinase is part of the family of alpha-kinases, whose catalytic domains display no sequence homology to conventional eukaryotic protein kinases []. This family also includes Dictyostelium myosin heavy chain kinases A, B, and C, and several mammalian putative protein kinases. The domain organisation of eEF-2 kinase appears to consist of two domains connected by a linker region, where the N-terminal domain contains the catalytic site, and the C-terminal domain contains the eEF-2 target region. The calmodulin-binding region is located between residues 51 and 96 [].

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR011990 Tetratricopeptide-like helical TPR-like_helical Domain
IPR004166 MHCK/EF2 kinase MHCK_EF2_kinase Domain
IPR006597 Sel1-like Sel1-like Repeat

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF038139 PIRSF IPR017400

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Elongation factor 2 kinase   GO:0004686 elongation factor-2 kinase activity
Elongation factor 2 kinase   GO:0005509 calcium ion binding
Elongation factor 2 kinase   GO:0005516 calmodulin binding
Elongation factor 2 kinase   GO:0006468 protein phosphorylation

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Elongation factor 2 kinase   GO:0004686 elongation factor-2 kinase activity
Elongation factor 2 kinase   GO:0005509 calcium ion binding
Elongation factor 2 kinase   GO:0005516 calmodulin binding
Elongation factor 2 kinase   GO:0006468 protein phosphorylation

0 Parent Features

4 Proteins

DB identifier Primary Accession
Organism . Name
A8XZH0_CAEBR A8XZH0 Caenorhabditis briggsae
G0N2N9_CAEBE G0N2N9 Caenorhabditis brenneri
EF2K_CAEEL O01991 Caenorhabditis elegans
EF2K_CAEEL-2 O01991-2 Caenorhabditis elegans