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Protein Domain : IPR000418

Name  Ets domain Short Name  Ets_dom
Type  Domain Description  Transcription factors are protein molecules that bind to specific DNAsequences in the genome, resulting in the induction or inhibition of genetranscription []. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [, , ]. This domain is rich inpositively-charged and aromatic residues, and binds to purine-rich segmentsof DNA. The ETS domain has been identified in other transcription factorssuch as PU.1, human erg, human elf-1, human elk-1, GA binding protein, anda number of others [, , ].It is generally localized at the C terminus of the protein,with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found atthe N terminus.NMR-analysis of the structure of the Ets domains revealed that it contains three alpha-helixes (1-3)and four-stranded beta-sheets (1-4) arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4 forming awinged helix-turn-helix (wHTH) topology []. The third alpha-helix isresponsive to contact to the major groove of the DNA. Different members of the Ets family proteinsdisplay distinct DNA binding specificities. The Ets domains and the flanking amino acid sequencesof the proteins influence the binding affinity, and the alteration of asingle amino acid in the Ets domain can change its DNA binding specificities.

Publication Counts Displayer

0 Child Features

0 Contains

6 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00178 PFAM IPR000418
PR00454 PRINTS IPR000418
PS00345 PROSITE IPR000418
PS00346 PROSITE IPR000418
PS50061 PROFILE IPR000418
SM00413 SMART IPR000418

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR016312 Transcription factor, GA-binding, alpha subunit TF_GA-bd_asu Family
IPR016311 Transforming protein C-ets Transform_prot_C-ets Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ets domain   GO:0003700 sequence-specific DNA binding transcription factor activity
Ets domain   GO:0043565 sequence-specific DNA binding
Ets domain   GO:0006355 regulation of transcription, DNA-templated

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ets domain   GO:0003700 sequence-specific DNA binding transcription factor activity
Ets domain   GO:0043565 sequence-specific DNA binding
Ets domain   GO:0006355 regulation of transcription, DNA-templated

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

126 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076762 P29774 Drosophila melanogaster
FBpp0074966 E2QCT0 Drosophila melanogaster
FBpp0099825 P11536 Drosophila melanogaster
FBpp0077522 Q01842 Drosophila melanogaster
FBpp0077739 P29776 Drosophila melanogaster
FBpp0084594 P29775 Drosophila melanogaster
FBpp0074965 P20105 Drosophila melanogaster
FBpp0084458 Q04688 Drosophila melanogaster
FBpp0088657 H8F4R1 Drosophila melanogaster
FBpp0088658 P51023 Drosophila melanogaster
FBpp0088656 P51022 Drosophila melanogaster
FBpp0089401 Q8MRW5 Drosophila melanogaster
FBpp0111767 A8DYS7 Drosophila melanogaster
FBpp0297063 M9NED0 Drosophila melanogaster
FBpp0274233 B5DPW2 Drosophila pseudoobscura
FBpp0274645 Q2M0U2 Drosophila pseudoobscura
FBpp0308947 B5DX51 Drosophila pseudoobscura
FBpp0280371 Q29N54 Drosophila pseudoobscura
FBpp0280544 Q29MI7 Drosophila pseudoobscura
FBpp0282882 Q29C04 Drosophila pseudoobscura
FBpp0283311 B5DYK1 Drosophila pseudoobscura
FBpp0283354 Q29BA6 Drosophila pseudoobscura
FBpp0161832 B4KWP7 Drosophila mojavensis
FBpp0162173 B4KZJ6 Drosophila mojavensis
FBpp0166188 B4KGB7 Drosophila mojavensis
FBpp0167244 B4KFH3 Drosophila mojavensis
FBpp0171245 B4KAR7 Drosophila mojavensis
FBpp0172366 B4KBS9 Drosophila mojavensis
FBpp0172428 B4KAW3 Drosophila mojavensis
FBpp0172783 B4K5J1 Drosophila mojavensis