modENCODE |  Help |  blog

Protein Domain : IPR020867

Name  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site Short Name  THF_DH/CycHdrlase_CS
Type  Conserved_site Description  Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF).Various reactions generate one-carbon derivatives of THF, which can be interconverted between differentoxidation states by methylene-THF dehydrogenase (), methenyl-THF cyclohydrolase ()and formyl-THF synthetase () [, ]. The dehydrogenase and cyclohydrolaseactivities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryoticC1-tetrahydrofolate synthase []; a bifunctional eukaryotic mitochondrial protein; and thebifunctional Escherichia colifolD protein [, ]. Methylene-tetrahydrofolate dehydrogenase andmethenyltetrahydrofolate cyclo-hydrolase share an overlapping active site [], and as such areusually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates otherthan peptide bonds.The sequence of the dehydrogenase/cyclohydrolase domain is highly conserved in all forms of the enzyme. This entry contains two conserved signature patterns; the first one is located in the N-terminal part of these enzymes and contains three acidic residues. The second pattern is a highly conserved sequence of 9 amino acids, which is located in the C-terminal section.

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00766 PROSITE IPR020867
PS00767 PROSITE IPR020867

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

3 Found In

DB identifier Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase THF_DH/CycHdrlase Family
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DH/CycHdrlase_NAD-bd_dom Domain

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site   GO:0003824 catalytic activity
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site   GO:0009396 folic acid-containing compound biosynthetic process
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site   GO:0055114 oxidation-reduction process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site   GO:0003824 catalytic activity
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site   GO:0009396 folic acid-containing compound biosynthetic process
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site   GO:0055114 oxidation-reduction process

0 Parent Features

17 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0099494 O96553 Drosophila melanogaster
FBpp0081476 Q04448 Drosophila melanogaster
FBpp0281021 Q293Q3 Drosophila pseudoobscura
FBpp0284787 Q294I2 Drosophila pseudoobscura
FBpp0159411 B4KBY8 Drosophila mojavensis
FBpp0172911 B4KD13 Drosophila mojavensis
FBpp0237670 B4LZJ8 Drosophila virilis
FBpp0237899 B4LX49 Drosophila virilis
FBpp0269811 B4PTZ7 Drosophila yakuba
FBpp0271053 B4PKR2 Drosophila yakuba
A8XQ07_CAEBR A8XQ07 Caenorhabditis briggsae
K7IEB9_CAEJA K7IEB9 Caenorhabditis japonica
G0MW70_CAEBE G0MW70 Caenorhabditis brenneri
Q21285_CAEEL Q21285 Caenorhabditis elegans
C1TC_DROME-2 O96553-2 Drosophila melanogaster
MTDC_DROME-2 Q04448-2 Drosophila melanogaster
E3MVI1_CAERE E3MVI1 Caenorhabditis remanei