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Protein Domain : IPR019585

Name  26S proteasome, regulatory subunit Rpn7 Short Name  26S_proteasome_reg_su-Rpn7
Type  Family Description  This entry represents the regulatory subunit RPN7 (known as the non-ATPase regulatory subunit 6 in higher eukaryotes) of the 26S proteasome. This entry also matches the evolutionarily related subunit 1 of the COP9 signalosome complex (CSN) from Arabidopsis []. The 26S proteasome plays a major role in ATP-dependent degradation of ubiquitinated proteins. Substrate specificity is conferred by the regulatory particle (RP), which can dissociate into stable lid and base subcomplexes. The regulatory subunit RPN7 is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae(Baker's yeast) to be required for structural integrity []. The COP9 signalosome is a conserved protein complex composed of eight subunits, where Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control []. The overall organisation and the amino acid sequences of the COP9 signalosome subunits resemble the lid subcomplex of the 19 S regulatory particle for the 26 S proteasome []. COP9 subunit 1 (CSN1 or GPS1) of the COP9 complex is an essential subunit of the complex with regard to both structural integrity and functionality. The N-terminal region of subunit 1 (CSN1-N) can inhibit c-fos expression from either a transfected template or a chromosomal transgene (fos-lacZ), and may contain the activity domain that confers most of the repression functions of CSN1. The C-terminal region of subunit 1 (CSN1-C) allows integration of the protein into the COP9 signalosome.

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0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PF10602 PFAM IPR019585

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

29 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0080233 Q9VJR9 Drosophila melanogaster
FBpp0074841 Q9VVU5 Drosophila melanogaster
FBpp0083687 Q9V3G7 Drosophila melanogaster
FBpp0282164 B5DYB0 Drosophila pseudoobscura
FBpp0278992 Q29P52 Drosophila pseudoobscura
FBpp0283940 Q298U4 Drosophila pseudoobscura
FBpp0286137 Q29DK4 Drosophila pseudoobscura
FBpp0160009 B4KC24 Drosophila mojavensis
FBpp0161044 B4KZ75 Drosophila mojavensis
FBpp0162356 B4KE58 Drosophila mojavensis
FBpp0226170 B4LS02 Drosophila virilis
FBpp0227944 B4LD47 Drosophila virilis
FBpp0228806 B4MB91 Drosophila virilis
FBpp0264058 B4P0V5 Drosophila yakuba
FBpp0267552 B4PH20 Drosophila yakuba
FBpp0267557 B4PH28 Drosophila yakuba
FBpp0269045 B4PLQ5 Drosophila yakuba
A8X0D1_CAEBR A8X0D1 Caenorhabditis briggsae
A8Y0P1_CAEBR A8Y0P1 Caenorhabditis briggsae
H2VKB7_CAEJA H2VKB7 Caenorhabditis japonica
H2WCB3_CAEJA H2WCB3 Caenorhabditis japonica
G0N0N6_CAEBE G0N0N6 Caenorhabditis brenneri
G0PEA8_CAEBE G0PEA8 Caenorhabditis brenneri
G0NWY4_CAEBE G0NWY4 Caenorhabditis brenneri
CSN1_CAEEL Q9GS00 Caenorhabditis elegans
PSMD6_CAEEL Q20585 Caenorhabditis elegans
E3N5P5_CAERE E3N5P5 Caenorhabditis remanei
E3NT33_CAERE E3NT33 Caenorhabditis remanei
E3N5P8_CAERE E3N5P8 Caenorhabditis remanei