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Protein Domain : IPR004367

Name  Cyclin, C-terminal domain Short Name  Cyclin_C-dom
Type  Domain Description  Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2(Herpesvirus saimiri) and Human herpesvirus 8(HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This is the C-terminal domain of cyclins.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF02984 PFAM IPR004367

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR013763 Cyclin-like Cyclin-like Domain
IPR014400 Cyclin A/B/D/E/F Cyclin_A/B/D/E/F Family
IPR015452 Cyclin B3, G2/mitotic-specific Cyclin_B3 Family
IPR015451 Cyclin D Cyclin_D Family
IPR015453 Cyclin A, chordates Cyclin_A_chordates Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cyclin, C-terminal domain   GO:0005634 nucleus

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cyclin, C-terminal domain   GO:0005634 nucleus

0 Parent Features

91 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070418 Q9W526 Drosophila melanogaster
FBpp0084103 Q9I7I0 Drosophila melanogaster
FBpp0080332 P54733 Drosophila melanogaster
FBpp0075808 F3YDG4 Drosophila melanogaster
FBpp0075807 P14785 Drosophila melanogaster
FBpp0082469 P25008 Drosophila melanogaster
FBpp0072987 Q9VZP3 Drosophila melanogaster
FBpp0071822 P20439 Drosophila melanogaster
FBpp0071824 C9QPI9 Drosophila melanogaster
FBpp0293192 M9NFR3 Drosophila melanogaster
FBpp0289621 Q7KUZ5 Drosophila melanogaster
FBpp0294012 M9NDQ2 Drosophila melanogaster
FBpp0285418 B5DSN9 Drosophila pseudoobscura
FBpp0277570 Q291N4 Drosophila pseudoobscura
FBpp0283237 B5DY97 Drosophila pseudoobscura
FBpp0279878 B5DIL4 Drosophila pseudoobscura
FBpp0280555 B5DID4 Drosophila pseudoobscura
FBpp0282452 Q29AI1 Drosophila pseudoobscura
FBpp0286898 Q29DY8 Drosophila pseudoobscura
FBpp0286985 B5DRS8 Drosophila pseudoobscura
FBpp0287381 Q29KE8 Drosophila pseudoobscura
FBpp0283001 Q29CG1 Drosophila pseudoobscura
FBpp0161600 B4KZK3 Drosophila mojavensis
FBpp0162669 B4KYV1 Drosophila mojavensis
FBpp0165617 B4L6N1 Drosophila mojavensis
FBpp0166509 B4KKY0 Drosophila mojavensis
FBpp0168441 B4KPB9 Drosophila mojavensis
FBpp0170818 B4L532 Drosophila mojavensis
FBpp0171412 B4K8C3 Drosophila mojavensis
FBpp0173490 B4K946 Drosophila mojavensis