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Protein Domain : IPR018201

Name  Beta-ketoacyl synthase, active site Short Name  Ketoacyl_synth_AS
Type  Active_site Description  Beta-ketoacyl-ACP synthase (KAS) []is the enzyme that catalyzesthe condensation of malonyl-ACP with the growing fatty acid chain. It is found as a componentof a number of enzymatic systems, including fatty acid synthetase (FAS), which catalyzes theformation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH; the multi-functional 6-methysalicylic acid synthase (MSAS) from Penicillium patulum[], which isinvolved in the biosynthesis of a polyketide antibiotic; polyketide antibiotic synthase enzymesystems; Emericella nidulansmultifunctional protein Wa, which is involved in the biosynthesisof conidial green pigment; Rhizobium nodulation protein nodE, which probably acts as a beta-ketoacyl synthase in the synthesis of the nodulation Nod factor fatty acyl chain; and yeastmitochondrial protein CEM1. The condensation reaction is a two step process, first the acylcomponent of an activated acyl primer is transferred to a cysteine residue of the enzyme andis then condensed with an activated malonyl donor with the concomitant release of carbondioxide.Beta-ketoacyl synthase also contains most of the structures involved in dimer formation.This entry represents the active site of beta-ketoacyl-ACP synthases [].

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0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00606 PROSITE IPR018201

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

6 Found In

DB identifier Name Short Name Type
IPR016039 Thiolase-like Thiolase-like Domain
IPR016038 Thiolase-like, subgroup Thiolase-like_subgr Domain
IPR014030 Beta-ketoacyl synthase, N-terminal Ketoacyl_synth_N Domain
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain PKS_Beta-ketoAc_synthase_dom Domain
IPR017568 3-oxoacyl-[acyl-carrier-protein]synthase 2 3-oxoacyl-ACP_synth-2 Family
IPR004432 Polyketide-type polyunsaturated fatty acid synthase, PfaA Omega_3_polyunsat_FA_synth Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

44 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0078358 Q9VNF5 Drosophila melanogaster
FBpp0077342 Q9VQL6 Drosophila melanogaster
FBpp0077343 Q9VQL7 Drosophila melanogaster
FBpp0297101 Q7PLB8 Drosophila melanogaster
FBpp0307370 M9PB21 Drosophila melanogaster
FBpp0307371 B7Z001 Drosophila melanogaster
FBpp0301234 B5DVP9 Drosophila pseudoobscura
FBpp0279845 Q29M08 Drosophila pseudoobscura
FBpp0279844 Q29M07 Drosophila pseudoobscura
FBpp0282230 B5DXU6 Drosophila pseudoobscura
FBpp0159726 B4KI47 Drosophila mojavensis
FBpp0159737 B4KI46 Drosophila mojavensis
FBpp0172424 B4KAW7 Drosophila mojavensis
FBpp0172582 B4K8H7 Drosophila mojavensis
FBpp0224776 B4M3T7 Drosophila virilis
FBpp0255160 B4PUV8 Drosophila yakuba
FBpp0236142 B4LRB3 Drosophila virilis
FBpp0236153 B4LRB2 Drosophila virilis
FBpp0237285 B4LXF7 Drosophila virilis
FBpp0263219 B4NXD5 Drosophila yakuba
FBpp0263220 B4NXD6 Drosophila yakuba
A8XFD1_CAEBR A8XFD1 Caenorhabditis briggsae
A8XKG1_CAEBR A8XKG1 Caenorhabditis briggsae
Q17301_CAEBR Q17301 Caenorhabditis briggsae
A8WWQ8_CAEBR A8WWQ8 Caenorhabditis briggsae
H2VID1_CAEJA H2VID1 Caenorhabditis japonica
H2VGA8_CAEJA H2VGA8 Caenorhabditis japonica
H2WEP1_CAEJA H2WEP1 Caenorhabditis japonica
K7I939_CAEJA K7I939 Caenorhabditis japonica
G0NXR3_CAEBE G0NXR3 Caenorhabditis brenneri