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Protein Domain : IPR016247

Name  Tyrosine-protein kinase, receptor ROR Short Name  Tyr_kinase_rcpt_ROR
Type  Family Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This group represents a tyrosine-protein kinase transmembrane receptor ROR family.

Publication Counts Displayer

0 Child Features

13 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR020635 Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom Domain
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR020067 Frizzled domain Frizzled_dom Domain
IPR000001 Kringle Kringle Domain
IPR013806 Kringle-like fold Kringle-like Domain
IPR018056 Kringle, conserved site Kringle_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000624 PIRSF IPR016247

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, receptor ROR   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, receptor ROR   GO:0005524 ATP binding
Tyrosine-protein kinase, receptor ROR   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, receptor ROR   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, receptor ROR   GO:0005524 ATP binding
Tyrosine-protein kinase, receptor ROR   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

0 Parent Features

8 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086841 Q9V6K3 Drosophila melanogaster
A8XXB9_CAEBR A8XXB9 Caenorhabditis briggsae
H2WDE8_CAEJA H2WDE8 Caenorhabditis japonica
G0NE97_CAEBE G0NE97 Caenorhabditis brenneri
G5ECA5_CAEEL G5ECA5 Caenorhabditis elegans
G5EGK5_CAEEL G5EGK5 Caenorhabditis elegans
Q38G54_CAEEL Q38G54 Caenorhabditis elegans
E3MHY0_CAERE E3MHY0 Caenorhabditis remanei