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Protein Domain : IPR001709

Name  Flavoprotein pyridine nucleotide cytochrome reductase Short Name  Flavoprot_Pyr_Nucl_cyt_Rdtase
Type  Domain Description  Flavoprotein pyridine nucleotide cytochrome reductases [](FPNCR) catalyse the interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes include ferredoxin:NADP+reductases (FNR) [], plant and fungal NAD(P)H:nitrate reductases [, ], NADH:cytochrome b5 reductases [], NADPH:P450 reductases [], NADPH:sulphite reductases [], nitric oxide synthases [], phthalate dioxygenase reductase [], and various other flavoproteins.Despite functional similarities, FPNCRs show no sequence similarity to NADPH:adrenodoxin reductases [], nor to bacterial ferredoxin:NAD+reductases and their homologues []. To date, 3D-structures of 4 members of the family have been solved: Spinacia oleracea(Spinach) ferredoxin:NADP+reductase []; Burkholderia cepacia(Pseudomonas cepacia)phthalate dioxygenase reductase []; the flavoprotein domain of Zea mays(Maize) nitrate reductase []; and Sus scrofa(Pig) NADH:cytochrome b5 reductase []. In all of them, the FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet with 2 helices on each side) []. In spite of such structural similarities, the level of amino acid identity between family members is at or below the limit of significance (e.g., nitrate reductase is only 15% identical to FNR) [].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR003097 FAD-binding, type 1 FAD-binding_1 Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR00371 PRINTS IPR001709

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

4 Found In

DB identifier Name Short Name Type
IPR001221 Phenol hydroxylase reductase Phe_hydroxylase Family
IPR010199 Sulphite reductase [NADPH]flavoprotein, alpha chain CysJ Family
IPR017634 Benzoyl-CoA oxygenase/reductase, BoxA protein Benzoyl_CoA_Oase_BoxA Family
IPR011884 Phenylacetate-CoA oxygenase/reductase, PaaK subunit PA_CoA_Oase5 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Flavoprotein pyridine nucleotide cytochrome reductase   GO:0016491 oxidoreductase activity
Flavoprotein pyridine nucleotide cytochrome reductase   GO:0055114 oxidation-reduction process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Flavoprotein pyridine nucleotide cytochrome reductase   GO:0016491 oxidoreductase activity
Flavoprotein pyridine nucleotide cytochrome reductase   GO:0055114 oxidation-reduction process

1 Parent Features

DB identifier Name Short Name Type
IPR001433 Oxidoreductase FAD/NAD(P)-binding OxRdtase_FAD/NAD-bd Domain

65 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079777 Q27571 Drosophila melanogaster
FBpp0078880 Q27597 Drosophila melanogaster
FBpp0078881 Q8IPJ7 Drosophila melanogaster
FBpp0075811 Q9I7R1 Drosophila melanogaster
FBpp0075810 Q4LDP7 Drosophila melanogaster
FBpp0076337 Q9VSJ5 Drosophila melanogaster
FBpp0082740 Q9VEV2 Drosophila melanogaster
FBpp0110168 Q0E8F4 Drosophila melanogaster
FBpp0110169 Q0E8F5 Drosophila melanogaster
FBpp0290358 E1JHY0 Drosophila melanogaster
FBpp0281499 Q295W6 Drosophila pseudoobscura
FBpp0285624 Q29JN6 Drosophila pseudoobscura
FBpp0286242 Q29DY6 Drosophila pseudoobscura
FBpp0287477 Q29KP6 Drosophila pseudoobscura
FBpp0161070 B4KYV3 Drosophila mojavensis
FBpp0160748 B4KFY5 Drosophila mojavensis
FBpp0162048 B4KYD9 Drosophila mojavensis
FBpp0167029 B4KKM7 Drosophila mojavensis
FBpp0171771 B4KBZ3 Drosophila mojavensis
FBpp0227223 B4LQV6 Drosophila virilis
FBpp0227390 B4LDS1 Drosophila virilis
FBpp0227968 B4LDM4 Drosophila virilis
FBpp0232056 B4LS74 Drosophila virilis
FBpp0238160 B4LX44 Drosophila virilis
FBpp0258305 B4P121 Drosophila yakuba
FBpp0258812 B4P0F6 Drosophila yakuba
FBpp0265186 B4PFQ1 Drosophila yakuba
FBpp0265750 B4PG29 Drosophila yakuba
FBpp0269406 B4PQZ4 Drosophila yakuba
A8XGQ2_CAEBR A8XGQ2 Caenorhabditis briggsae