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Protein Domain : IPR001876

Name  Zinc finger, RanBP2-type Short Name  Znf_RanBP2
Type  Domain Description  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents the zinc finger domain found in RanBP2 proteins. Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran binding protein 2 (RanBP2) is a 358kDa nucleoporin located on the cytoplasmic side of the nuclear pore complex which plays a role in nuclear protein import []. RanBP2 contains multiple zinc fingers which mediate binding to RanGDP [].

Publication Counts Displayer

0 Child Features

0 Contains

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00641 PFAM IPR001876
PS01358 PROSITE IPR001876
PS50199 PROFILE IPR001876
SM00547 SMART IPR001876
G3DSA:4.10.1060.10 GENE3D IPR001876

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

4 Found In

DB identifier Name Short Name Type
IPR017337 Uncharacterised conserved protein UCP037956, zinc finger Ran-binding UCP037956_Znf_RanB2 Family
IPR015458 MDM4 MDM4 Family
IPR016495 p53 negative regulator Mdm2/Mdm4 p53_neg-reg_MDM_2/4 Family
IPR015459 Ubiquitin-protein ligase E3 MDM2 MDM2_E3_ligase Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Zinc finger, RanBP2-type   GO:0008270 zinc ion binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Zinc finger, RanBP2-type   GO:0008270 zinc ion binding

0 Parent Features

153 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0303663 M9PCD7 Drosophila melanogaster
FBpp0303658 Q8IPJ3 Drosophila melanogaster
FBpp0303660 M9PB55 Drosophila melanogaster
FBpp0303662 M9PCS0 Drosophila melanogaster
FBpp0288734 Q9VM88 Drosophila melanogaster
FBpp0303661 M9PC77 Drosophila melanogaster
FBpp0071779 Q9W215 Drosophila melanogaster
FBpp0072188 Q9W1A4 Drosophila melanogaster
FBpp0085704 Q6NQZ7 Drosophila melanogaster
FBpp0081902 Q9VGJ3 Drosophila melanogaster
FBpp0084267 Q9VBP9 Drosophila melanogaster
FBpp0084188 Q9VBU7 Drosophila melanogaster
FBpp0077631 Q9VPY4 Drosophila melanogaster
FBpp0073996 Q27294 Drosophila melanogaster
FBpp0088620 P27398 Drosophila melanogaster
FBpp0088619 F3YDK6 Drosophila melanogaster
FBpp0290798 E1JJ98 Drosophila melanogaster
FBpp0071847 Q9W230 Drosophila melanogaster
FBpp0077633 A0A023GRW3 Drosophila melanogaster
FBpp0307001 M9PH94 Drosophila melanogaster
FBpp0309144 A8JV18 Drosophila melanogaster
FBpp0074059 Q9VXE6 Drosophila melanogaster
FBpp0111979 A8DYA3 Drosophila melanogaster
FBpp0087193 A1Z8M2 Drosophila melanogaster
FBpp0081569 Q9VH90 Drosophila melanogaster
FBpp0300589 I5APC2 Drosophila pseudoobscura
FBpp0281566 Q296G8 Drosophila pseudoobscura
FBpp0300588 I5APC1 Drosophila pseudoobscura
FBpp0272628 B5DN33 Drosophila pseudoobscura
FBpp0276627 Q290H2 Drosophila pseudoobscura