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Protein Domain : IPR014752

Name  Arrestin, C-terminal Short Name  Arrestin_C
Type  Domain Description  Arrestinscomprise a family of closely-related proteins. In addition to the inactivation of G protein-coupled receptors, arrestins have been implicated in the endocytosis of receptors and cross talk with other signalling pathways. S-Arrestin (retinal S-antigen) is a major protein of the retinal rod outer segments. It interacts with photo-activated phosphorylated rhodopsin, inhibiting or 'arresting' its ability to interact with transducin []. Beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X) [], which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction [, , ].The crystal structure of bovine retinal arrestin comprises two domains of antiparallel beta-sheets connected through a hinge region and one short alpha-helix on the back of the amino-terminal fold []. This entry represents the C-terminal domain of arrestin, consisting of an immunoglobulin-like beta-sandwich structure.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:2.60.40.640 GENE3D IPR014752

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain
IPR000698 Arrestin Arrestin Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Arrestin, C-terminal   GO:0007165 signal transduction

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Arrestin, C-terminal   GO:0007165 signal transduction

1 Parent Features

DB identifier Name Short Name Type
IPR011022 Arrestin C-terminal-like domain Arrestin_C-like Domain

74 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0071397 Q9W2V2 Drosophila melanogaster
FBpp0080583 P15372 Drosophila melanogaster
FBpp0076326 P19107 Drosophila melanogaster
FBpp0085236 Q9V393 Drosophila melanogaster
FBpp0072433 Q0E8K8 Drosophila melanogaster
FBpp0278984 Q29LC9 Drosophila pseudoobscura
FBpp0281821 Q29H45 Drosophila pseudoobscura
FBpp0281954 Q298D4 Drosophila pseudoobscura
FBpp0286677 Q29EU1 Drosophila pseudoobscura
FBpp0287160 Q29D09 Drosophila pseudoobscura
FBpp0284851 Q293Z7 Drosophila pseudoobscura
FBpp0161631 B4KZ69 Drosophila mojavensis
FBpp0162006 B4KXX5 Drosophila mojavensis
FBpp0164609 B4L2E8 Drosophila mojavensis
FBpp0167154 B4KEG0 Drosophila mojavensis
FBpp0172012 B4K866 Drosophila mojavensis
FBpp0226724 B4LEM0 Drosophila virilis
FBpp0229096 B4MHF0 Drosophila virilis
FBpp0229206 B4MEF1 Drosophila virilis
FBpp0230506 B4MGQ2 Drosophila virilis
FBpp0232126 B4LSW4 Drosophila virilis
FBpp0237215 B4LY88 Drosophila virilis
FBpp0257819 B4P8N4 Drosophila yakuba
FBpp0260403 B4PXI9 Drosophila yakuba
FBpp0268299 B4PP42 Drosophila yakuba
A8X5S0_CAEBR A8X5S0 Caenorhabditis briggsae
A8WP32_CAEBR A8WP32 Caenorhabditis briggsae
A8WP43_CAEBR A8WP43 Caenorhabditis briggsae
A8WP37_CAEBR A8WP37 Caenorhabditis briggsae
A8WP41_CAEBR A8WP41 Caenorhabditis briggsae