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Protein Domain : IPR018254

Name  Ribosomal protein L29, conserved site Short Name  Ribosomal_L29_CS
Type  Conserved_site Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Ribosomal protein L29 is one of the proteins from the large ribosomal subunit. L29 belongs to a family of ribosomal proteins of 63 to 138 amino-acid residues which, on the basis of sequence similarities [], groups:Red algal L29.Bacterial L29.Mammalian L35Caenorhabditis elegansL35 (ZK652.4).Yeast L35.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00579 PROSITE IPR018254

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR001854 Ribosomal protein L29 Ribosomal_L29 Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L29, conserved site   GO:0003735 structural constituent of ribosome
Ribosomal protein L29, conserved site   GO:0006412 translation
Ribosomal protein L29, conserved site   GO:0005622 intracellular
Ribosomal protein L29, conserved site   GO:0005840 ribosome

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L29, conserved site   GO:0003735 structural constituent of ribosome
Ribosomal protein L29, conserved site   GO:0006412 translation
Ribosomal protein L29, conserved site   GO:0005622 intracellular
Ribosomal protein L29, conserved site   GO:0005840 ribosome

0 Parent Features

11 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070767 Q9W499 Drosophila melanogaster
FBpp0285477 Q29I12 Drosophila pseudoobscura
FBpp0165465 B4L641 Drosophila mojavensis
FBpp0231130 B4M807 Drosophila virilis
A8XF40_CAEBR A8XF40 Caenorhabditis briggsae
H2VGY8_CAEJA H2VGY8 Caenorhabditis japonica
G0MGK0_CAEBE G0MGK0 Caenorhabditis brenneri
RL35_CAEEL P34662 Caenorhabditis elegans
Q8MT59_DROME Q8MT59 Drosophila melanogaster
B4PZC7_DROYA B4PZC7 Drosophila yakuba
E3MKT1_CAERE E3MKT1 Caenorhabditis remanei