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Protein Domain : IPR018122

Name  Transcription factor, fork head, conserved site Short Name  TF_fork_head_CS
Type  Conserved_site Description  The fork head protein of Drosophila melanogaster, a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors []. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiaeHCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [, , ].The fork head domain binds B-DNA as a monomer [], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00657 PROSITE IPR018122
PS00658 PROSITE IPR018122

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001766 Transcription factor, fork head TF_fork_head Domain

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor, fork head, conserved site   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription factor, fork head, conserved site   GO:0043565 sequence-specific DNA binding
Transcription factor, fork head, conserved site   GO:0006355 regulation of transcription, DNA-templated

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor, fork head, conserved site   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription factor, fork head, conserved site   GO:0043565 sequence-specific DNA binding
Transcription factor, fork head, conserved site   GO:0006355 regulation of transcription, DNA-templated

0 Parent Features

224 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0304899 M9PI07 Drosophila melanogaster
FBpp0304900 M9PC64 Drosophila melanogaster
FBpp0304898 M9PF47 Drosophila melanogaster
FBpp0291179 Q0E8F8 Drosophila melanogaster
FBpp0290009 Q8IQE9 Drosophila melanogaster
FBpp0307179 Q9W4Q1 Drosophila melanogaster
FBpp0081715 Q9XTP7 Drosophila melanogaster
FBpp0078049 P32027 Drosophila melanogaster
FBpp0071036 Q9W3Q5 Drosophila melanogaster
FBpp0073048 Q02360 Drosophila melanogaster
FBpp0302969 Q9VH87 Drosophila melanogaster
FBpp0084145 P32028 Drosophila melanogaster
FBpp0077189 H5V8D4 Drosophila melanogaster
FBpp0088311 Q9V481 Drosophila melanogaster
FBpp0071809 Q02361 Drosophila melanogaster
FBpp0084146 P32029 Drosophila melanogaster
FBpp0076609 Q9VS05 Drosophila melanogaster
FBpp0084690 P14734 Drosophila melanogaster
FBpp0077188 Q961V5 Drosophila melanogaster
FBpp0089343 Q95V55 Drosophila melanogaster
FBpp0070031 Q9W5X5 Drosophila melanogaster
FBpp0301970 M9PDZ5 Drosophila melanogaster
FBpp0288346 Q29F32 Drosophila pseudoobscura
FBpp0288343 B5DPA5 Drosophila pseudoobscura
FBpp0273873 Q29CT5 Drosophila pseudoobscura
FBpp0282082 Q298W7 Drosophila pseudoobscura
FBpp0279983 Q29MF9 Drosophila pseudoobscura
FBpp0274054 B5DNG4 Drosophila pseudoobscura
FBpp0274139 Q2LZ32 Drosophila pseudoobscura
FBpp0279984 Q29MG0 Drosophila pseudoobscura