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Protein Domain : IPR001440

Name  Tetratricopeptide TPR1 Short Name  TPR_1
Type  Repeat Description  The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed thatTPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees; within asingle TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface iscontributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00515 PFAM IPR001440

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR011990 Tetratricopeptide-like helical TPR-like_helical Domain
IPR013026 Tetratricopeptide repeat-containing domain TPR-contain_dom Domain
IPR002151 Kinesin light chain Kinesin_light Family
IPR011236 Serine/threonine protein phosphatase 5 Ser/Thr_PPase_5 Family
IPR005687 Mitochondrial outer membrane translocase complex, subunit Tom70 Tom70 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetratricopeptide TPR1   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetratricopeptide TPR1   GO:0005515 protein binding

0 Parent Features

235 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070351 O46085 Drosophila melanogaster
FBpp0070352 Q7KW08 Drosophila melanogaster
FBpp0081606 Q9VH81 Drosophila melanogaster
FBpp0080894 Q9I7L8 Drosophila melanogaster
FBpp0080535 Q9VJD4 Drosophila melanogaster
FBpp0082765 Q9VEV3 Drosophila melanogaster
FBpp0075683 P46824 Drosophila melanogaster
FBpp0079468 Q9VL78 Drosophila melanogaster
FBpp0070907 Q9W3Y6 Drosophila melanogaster
FBpp0077614 Q9V3X5 Drosophila melanogaster
FBpp0293601 A8DYS8 Drosophila melanogaster
FBpp0077790 Q9VPN5 Drosophila melanogaster
FBpp0070908 Q8IRQ6 Drosophila melanogaster
FBpp0086164 Q7JVW5 Drosophila melanogaster
FBpp0076600 Q9VS37 Drosophila melanogaster
FBpp0071879 Q9W1T9 Drosophila melanogaster
FBpp0072164 Q9V3E9 Drosophila melanogaster
FBpp0080423 Q9V3W1 Drosophila melanogaster
FBpp0080424 Q8IP18 Drosophila melanogaster
FBpp0088148 Q7K4Y8 Drosophila melanogaster
FBpp0072562 Q7K0X3 Drosophila melanogaster
FBpp0079851 Q9VKG0 Drosophila melanogaster
FBpp0085422 Q7KJA9 Drosophila melanogaster
FBpp0309502 Q7KRS6 Drosophila melanogaster
FBpp0290395 Q9V9R6 Drosophila melanogaster
FBpp0081552 Q9VHA8 Drosophila melanogaster
FBpp0079664 Q9VL07 Drosophila melanogaster
FBpp0290896 Q9VQE9 Drosophila melanogaster
FBpp0292906 M9MRG4 Drosophila melanogaster
FBpp0305670 M9PDJ9 Drosophila melanogaster