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Protein Domain : IPR000591

Name  DEP domain Short Name  DEP_dom
Type  Domain Description  This entry represents the DEP (Dishevelled, Egl-10 and Pleckstrin) domain, a globular domain of about 80 residues that is found in over 50 proteins involved in G-protein signalling pathways. It was named after the three proteins it was initially found in:Dishevelled (Dsh and Dvl), which play a key role in the transduction of the Wg/Wnt signal from the cell surface to the nucleus; it is a segment polarity protein required to establish coherent arrays of polarized cells and segments in embryos, and plays a role in wingless signalling.Egl-10, which regulates G-protein signalling in the central nervous system. Pleckstrin, the major substrate of protein kinase C in platelets; Pleckstrin contains two PH domains flanking the DEP domain.Mammalian regulators of G-protein signalling also contain these domains, and regulate signal transduction by increasing the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. It has been proposed that the DEP domain could play a selective role in targeting DEP domain-containing proteins to specific subcellular membranous sites, perhaps even to specific G protein-coupled signaling pathways [, ]. Nuclear magnetic resonance spectroscopy has revealed that the DEP domain comprises a three-helix bundle, a beta-hairpin 'arm' composed of two beta-strands and two short beta-strands in the C-terminal region [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00610 PFAM IPR000591
PS50186 PROFILE IPR000591
SM00049 SMART IPR000591

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR008339 Dishevelled family Dishevelled_fam Family
IPR015506 Dishevelled-related protein Dsh/Dvl-rel Family
IPR008340 Dishevelled-1 Dishevelled_1 Family
IPR008342 Dishevelled-3 Dishevelled_3 Family
IPR008341 Dishevelled-2 Dishevelled_2 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
DEP domain   GO:0035556 intracellular signal transduction

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
DEP domain   GO:0035556 intracellular signal transduction

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

93 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0088523 O96838 Drosophila melanogaster
FBpp0073310 P51140 Drosophila melanogaster
FBpp0074947 Q9VVJ0 Drosophila melanogaster
FBpp0074124 Q9VXA3 Drosophila melanogaster
FBpp0111548 Q7K3Z6 Drosophila melanogaster
FBpp0289455 Q9VWP8 Drosophila melanogaster
FBpp0302026 M9PHI8 Drosophila melanogaster
FBpp0305332 M9PFK5 Drosophila melanogaster
FBpp0281508 Q29H20 Drosophila pseudoobscura
FBpp0272200 Q29FZ9 Drosophila pseudoobscura
FBpp0274531 B5DPH6 Drosophila pseudoobscura
FBpp0275965 Q28XF3 Drosophila pseudoobscura
FBpp0277143 B5E1B7 Drosophila pseudoobscura
FBpp0285510 Q29FK8 Drosophila pseudoobscura
FBpp0161605 B4KZJ3 Drosophila mojavensis
FBpp0163344 B4L7H1 Drosophila mojavensis
FBpp0164928 B4L498 Drosophila mojavensis
FBpp0165062 B4L4X2 Drosophila mojavensis
FBpp0169448 B4KNH3 Drosophila mojavensis
FBpp0169654 B4KQV2 Drosophila mojavensis
FBpp0226695 B4LEZ2 Drosophila virilis
FBpp0229657 B4MCY6 Drosophila virilis
FBpp0233753 B4M1M5 Drosophila virilis
FBpp0234213 B4MGH9 Drosophila virilis
FBpp0234526 B4LKS5 Drosophila virilis
FBpp0234598 B4LK83 Drosophila virilis
FBpp0260648 B4Q1W4 Drosophila yakuba
FBpp0260937 B4PYC2 Drosophila yakuba
FBpp0262760 B4PWF7 Drosophila yakuba
FBpp0264932 B4PJL1 Drosophila yakuba