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Protein Domain : IPR020635

Name  Tyrosine-protein kinase, catalytic domain Short Name  Tyr_kinase_cat_dom
Type  Domain Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].
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Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site Tyr_kinase_rcpt_2_CS Conserved_site
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site Tyr_kinase_rcpt_3_CS Conserved_site

1 Cross References

Identifier
Source . Name
Subject . Primary Identifier
SM00219 SMART IPR020635

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

23 Found In

DB identifier Name Short Name Type
IPR020766 Receptor-like tyrosine-protein kinase kin-15/kin-16 kin-15/kin-16 Family
IPR016247 Tyrosine-protein kinase, receptor ROR Tyr_kinase_rcpt_ROR Family
IPR016257 Ephrin receptor type-A /type-B Tyr_kinase_ephrin_rcpt Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR2_rcpt Family
IPR020691 Ephrin type-A receptor 8 EphrinA_rcpt8 Family
IPR016246 Tyrosine-protein kinase, insulin-like receptor Tyr_kinase_insulin-like_rcpt Family
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2 Tyr_kinase_non-rcpt_Jak/Tyk2 Family
IPR020693 Tyrosine-protein kinase, non-receptor Jak2 Tyr_kinase_non-rcpt_Jak2 Family
IPR020775 Tyrosine-protein kinase, non-receptor Jak3 Tyr_kinase_non-rcpt_Jak3 Family
IPR020776 Tyrosine-protein kinase, non-receptor Jak1 Tyr_kinase_non-rcpt_Jak1 Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyr_kinase_neurotrophic_rcpt_1 Family
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70 Tyr_kinase_non-rcpt_SYK/ZAP70 Family
IPR015785 Mitogen-activated protein (MAP) kinase kinase kinase 10 MAP3K10 Family
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11 MAPKKK9/10/11 Family
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor Tyr_kinase_CSF1/PDGF_rcpt Family
IPR016250 Tyrosine-protein kinase, Fes/Fps type Tyr-prot_kinase_Fes/Fps Family
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor Tyr_kinase_EGF/ERB/XmrK_rcpt Family
IPR016244 Tyrosine-protein kinase, HGF/MSP receptor Tyr_kinase_HGF/MSP_rcpt Family
IPR016249 Tyrosine-protein kinase, Ret receptor Tyr_kinase_Ret_rcpt Family

2 GO Annotation


Subject . Secondary Identifier
Subject . Name
Subject . Symbol
Ontology Term . Identifier
Ontology Term . Name
Tyrosine-protein kinase, catalytic domain   GO:0004713 protein tyrosine kinase activity
Tyrosine-protein kinase, catalytic domain   GO:0006468 protein phosphorylation

2 Ontology Annotations


Subject . Secondary Identifier
Subject . Name
Subject . Symbol
Ontology Term . Identifier
Ontology Term . Name
Tyrosine-protein kinase, catalytic domain   GO:0004713 protein tyrosine kinase activity
Tyrosine-protein kinase, catalytic domain   GO:0006468 protein phosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain

539 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0080736 Q27324 Drosophila melanogaster
FBpp0303242 M9PDD9 Drosophila melanogaster
FBpp0099944 P00528 Drosophila melanogaster
FBpp0100143 Q09147 Drosophila melanogaster
FBpp0307254 Q9V9J3 Drosophila melanogaster
FBpp0112952 Q8IQ00 Drosophila melanogaster
FBpp0088151 Q0KIF4 Drosophila melanogaster
FBpp0088152 Q8IMC2 Drosophila melanogaster
FBpp0088153 Q9V4E5 Drosophila melanogaster
FBpp0088154 Q59DQ4 Drosophila melanogaster
FBpp0086264 Q7KJ08 Drosophila melanogaster
FBpp0087135 Q6AWJ9 Drosophila melanogaster
FBpp0073067 Q9VZI2 Drosophila melanogaster
FBpp0082971 Q07407 Drosophila melanogaster
FBpp0079568 Q24488 Drosophila melanogaster
FBpp0303361 Q9I7F7 Drosophila melanogaster
FBpp0086382 Q24145 Drosophila melanogaster
FBpp0085728 Q0E917 Drosophila melanogaster
FBpp0081022 Q7KT06 Drosophila melanogaster
FBpp0081530 P18106 Drosophila melanogaster
FBpp0071570 Q8MLW0 Drosophila melanogaster
FBpp0083519 P09208 Drosophila melanogaster
FBpp0073313 Q24592 Drosophila melanogaster
FBpp0079236 P08630 Drosophila melanogaster
FBpp0080765 Q9V422 Drosophila melanogaster
FBpp0113097 B7YZL9 Drosophila melanogaster
FBpp0075116 P00522 Drosophila melanogaster
FBpp0084248 Q9VBW3 Drosophila melanogaster
FBpp0073179 Q9VZA8 Drosophila melanogaster
FBpp0088012 P18475 Drosophila melanogaster




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