modENCODE |  Help |  blog

Protein Domain : IPR003961

Name  Fibronectin, type III Short Name  Fibronectin_type3
Type  Domain Description  Fibronectins are multi-domain glycoproteins found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes []. They contain multiple copies of 3 repeat regions (types I, II and III), which bind to a variety of substances including heparin, collagen, DNA, actin, fibrin and fibronectin receptors on cell surfaces. The wide variety of these substances means that fibronectins are involved in a number of important functions: e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis []. The role of fibronectin in cell differentiation is demonstrated by the marked reduction in the expression of its gene when neoplastic transformation occurs. Cell attachment has been found to be mediated by the binding of the tetrapeptide RGDS to integrins on the cell surface [], although related sequences can also display cell adhesion activity.Plasma fibronectin occurs as a dimer of 2 different subunits, linked together by 2 disulphide bonds near the C terminus. The difference in the 2 chains occurs in the type III repeat region and is caused by alternative splicing of the mRNA from one gene []. The observation that, in a given protein, an individual repeat of one of the 3 types (e.g., the first FnIII repeat) shows much less similarity to its subsequent tandem repeats within that protein than to its equivalent repeat between fibronectins from other species, has suggested that the repeating structure of fibronectin arose at an early stage of evolution. It also seems to suggest that the structure is subject to high selective pressure [].The fibronectin type III repeat region is an approximately 100 amino acid domain, different tandem repeats of which contain binding sites for DNA, heparin and the cell surface []. The superfamily of sequences believed to contain FnIII repeats represents 45 different families, the majority of which are involved in cell surface binding in some manner, or are receptor protein tyrosine kinases, or cytokine receptors.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site Hematopoietin_rcpt_Gp130_CS Conserved_site
IPR003528 Long hematopoietin receptor, single chain, conserved site Long_hematopoietin_rcpt_CS Conserved_site
IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site Hematopoietin_rcpt_L_F3_CS Conserved_site
IPR003531 Short hematopoietin receptor, family 1, conserved site Hempt_rcpt_S_F1_CS Conserved_site

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00041 PFAM IPR003961
PF01108 PFAM IPR003961
PS50853 PROFILE IPR003961
SM00060 SMART IPR003961
SSF49265 SSF IPR003961

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

15 Found In

DB identifier Name Short Name Type
IPR020766 Receptor-like tyrosine-protein kinase kin-15/kin-16 kin-15/kin-16 Family
IPR019326 Protein of unknown function DUF2369 DUF2369 Family
IPR016257 Ephrin receptor type-A /type-B Tyr_kinase_ephrin_rcpt Family
IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain IL3_rcpt_beta Family
IPR009167 Erythropoietin receptor Erythropoietin_rcpt Family
IPR016669 Interferon alpha/beta receptor 1 Interferon_alpha/beta_rcpt-1 Family
IPR016246 Tyrosine-protein kinase, insulin-like receptor Tyr_kinase_insulin-like_rcpt Family
IPR015528 Interleukin-12 beta IL-12_beta Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family
IPR020682 Obscurin-myosin light chain kinase Obscurin-myosin_light-ch_kin Family
IPR015752 Leptin receptor Lep_receptor Family
IPR012013 Integrin beta-4 subunit Integrin_bsu-4 Family
IPR014390 Acid phosphatase, Aspergillus type Acid_Pase_Asper Family
IPR016335 Leukocyte common antigen Leukocyte_common_ag Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Fibronectin, type III   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Fibronectin, type III   GO:0005515 protein binding

1 Parent Features

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain

945 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0293057 M9MRI4 Drosophila melanogaster
FBpp0079685 Q86P21 Drosophila melanogaster
FBpp0304922 M9PGY4 Drosophila melanogaster
FBpp0304923 M9PBI9 Drosophila melanogaster
FBpp0304926 M9PDZ9 Drosophila melanogaster
FBpp0304930 M9PEA9 Drosophila melanogaster
FBpp0304928 M9PBJ0 Drosophila melanogaster
FBpp0304929 M9PDS8 Drosophila melanogaster
FBpp0304921 M9PDZ6 Drosophila melanogaster
FBpp0304927 M9PGZ0 Drosophila melanogaster
FBpp0304925 M9PEA5 Drosophila melanogaster
FBpp0304924 M9PDS3 Drosophila melanogaster
FBpp0304920 M9PEA0 Drosophila melanogaster
FBpp0300448 Q9VQW1 Drosophila melanogaster
FBpp0300447 M9NCR3 Drosophila melanogaster
FBpp0080718 Q9VJ04 Drosophila melanogaster
FBpp0293362 Q86BP0 Drosophila melanogaster
FBpp0083934 Q9VCC7 Drosophila melanogaster
FBpp0088091 A1Z6X1 Drosophila melanogaster
FBpp0110381 Q0E9I2 Drosophila melanogaster
FBpp0110373 Q0E9J2 Drosophila melanogaster
FBpp0110378 Q0E9I0 Drosophila melanogaster
FBpp0088088 Q0E9H9 Drosophila melanogaster
FBpp0110367 Q0E9M2 Drosophila melanogaster
FBpp0110346 Q0E9J8 Drosophila melanogaster
FBpp0110384 Q0E9I4 Drosophila melanogaster
FBpp0110344 Q0E9J6 Drosophila melanogaster
FBpp0110368 Q0E9M3 Drosophila melanogaster
FBpp0110371 Q0E9K4 Drosophila melanogaster
FBpp0110345 Q0E9J7 Drosophila melanogaster