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Protein Domain : IPR005484

Name  Ribosomal protein L18/L5 Short Name  Ribosomal_L18/L5
Type  Family Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].This family includes L18 from bacteria and L5 from eukaryotes. The ribosomal 5S RNA isthe only known rRNA species to bind a ribosomal protein before its assembly into theribosomal subunits []. In eukaryotes, the 5S rRNA molecule binds one protein species, a 34kDa protein which has been implicated in the intracellulartransport of 5 S rRNA, while in bacteria it bindstwo or three different protein species [].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal Rbsml_L5_euk/L18_arc Family
IPR004389 Ribosomal protein L18, bacterial-type Ribosomal_L18_bac-type Family

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00861 PFAM IPR005484

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L18/L5   GO:0003735 structural constituent of ribosome
Ribosomal protein L18/L5   GO:0006412 translation
Ribosomal protein L18/L5   GO:0005622 intracellular
Ribosomal protein L18/L5   GO:0005840 ribosome

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein L18/L5   GO:0003735 structural constituent of ribosome
Ribosomal protein L18/L5   GO:0006412 translation
Ribosomal protein L18/L5   GO:0005622 intracellular
Ribosomal protein L18/L5   GO:0005840 ribosome

0 Parent Features

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0110424 Q9W5R8 Drosophila melanogaster
FBpp0287271 B5DK39 Drosophila pseudoobscura
FBpp0166701 B4KFT7 Drosophila mojavensis
FBpp0229463 B4LQQ5 Drosophila virilis
FBpp0260289 B4IT18 Drosophila yakuba
RL5_CAEBR Q627R7 Caenorhabditis briggsae
H2VVA8_CAEJA H2VVA8 Caenorhabditis japonica
G0NFK9_CAEBE G0NFK9 Caenorhabditis brenneri
G0NFL5_CAEBE G0NFL5 Caenorhabditis brenneri
RL5_CAEEL P49405 Caenorhabditis elegans
Q6NMY6_DROME Q6NMY6 Drosophila melanogaster
E3LGF0_CAERE E3LGF0 Caenorhabditis remanei