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Protein Domain : IPR013098

Name  Immunoglobulin I-set Short Name  Ig_I-set
Type  Domain Description  The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ), C1-set (constant-1; ), C2-set (constant-2; ) and I-set (intermediate; ) []. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [, ].Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system []. This entry represents I-set domains, which are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1 [], and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis [].

Publication Counts Displayer

0 Child Features

2 Contains

DB identifier Name Short Name Type
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain

1 Cross References

Source . Name

Subject . Primary Identifier
PF07679 PFAM IPR013098

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

20 Found In

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR016247 Tyrosine-protein kinase, receptor ROR Tyr_kinase_rcpt_ROR Family
IPR009138 Neural cell adhesion Neural_cell_adh Family
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25 IGFBP_rP_mac25 Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR009151 Basigin Basigin Family
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR2_rcpt Family
IPR009137 Vascular endothelial growth factor receptor 3(VEGFR3) VEGFR3_rcpt Family
IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1) VEGFR1_rcpt Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family
IPR020682 Obscurin-myosin light chain kinase Obscurin-myosin_light-ch_kin Family
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor Tyr_kinase_CSF1/PDGF_rcpt Family
IPR018250 Neuregulin Neuregulin Family
IPR003989 Vascular cell adhesion molecule-1 VCAM-1 Family
IPR004076 Interleukin-1 receptor type 1 IL-1_rcpt_I-typ Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1134 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289176 B7Z153 Drosophila melanogaster
FBpp0070535 Q9W4T9 Drosophila melanogaster
FBpp0304922 M9PGY4 Drosophila melanogaster
FBpp0304923 M9PBI9 Drosophila melanogaster
FBpp0304926 M9PDZ9 Drosophila melanogaster
FBpp0304930 M9PEA9 Drosophila melanogaster
FBpp0304928 M9PBJ0 Drosophila melanogaster
FBpp0304929 M9PDS8 Drosophila melanogaster
FBpp0304921 M9PDZ6 Drosophila melanogaster
FBpp0304927 M9PGZ0 Drosophila melanogaster
FBpp0301063 M9NDX0 Drosophila melanogaster
FBpp0304925 M9PEA5 Drosophila melanogaster
FBpp0304924 M9PDS3 Drosophila melanogaster
FBpp0304920 M9PEA0 Drosophila melanogaster
FBpp0300448 Q9VQW1 Drosophila melanogaster
FBpp0300447 M9NCR3 Drosophila melanogaster
FBpp0076037 Q9VT83 Drosophila melanogaster
FBpp0303942 M9PF17 Drosophila melanogaster
FBpp0086751 A1Z9G5 Drosophila melanogaster
FBpp0081202 Q8MRE6 Drosophila melanogaster
FBpp0070537 Q08180 Drosophila melanogaster
FBpp0100143 Q09147 Drosophila melanogaster
FBpp0085182 Q9V9V6 Drosophila melanogaster
FBpp0088091 A1Z6X1 Drosophila melanogaster
FBpp0110381 Q0E9I2 Drosophila melanogaster
FBpp0110373 Q0E9J2 Drosophila melanogaster
FBpp0110378 Q0E9I0 Drosophila melanogaster
FBpp0088088 Q0E9H9 Drosophila melanogaster
FBpp0110367 Q0E9M2 Drosophila melanogaster
FBpp0110346 Q0E9J8 Drosophila melanogaster