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Protein Domain : IPR007110

Name  Immunoglobulin-like domain Short Name  Ig-like_dom
Type  Domain Description  The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ), C1-set (constant-1; ), C2-set (constant-2; ) and I-set (intermediate; ) []. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [, ].Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system [].

Publication Counts Displayer

0 Child Features

9 Contains

DB identifier Name Short Name Type
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain
IPR013106 Immunoglobulin V-set domain Ig_V-set Domain
IPR013151 Immunoglobulin Immunoglobulin Domain
IPR013162 CD80-like, immunoglobulin C2-set CD80_C2-set Domain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved site Ig/MHC_CS Conserved_site
IPR003597 Immunoglobulin C1-set Ig_C1-set Domain
IPR003596 Immunoglobulin V-set, subgroup Ig_V-set_subgr Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS50835 PROFILE IPR007110

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

38 Found In

DB identifier Name Short Name Type
IPR016247 Tyrosine-protein kinase, receptor ROR Tyr_kinase_rcpt_ROR Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25 IGFBP_rP_mac25 Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR013270 CD47 immunoglobulin-like CD47_Vset Domain
IPR009151 Basigin Basigin Family
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR2_rcpt Family
IPR009137 Vascular endothelial growth factor receptor 3(VEGFR3) VEGFR3_rcpt Family
IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1) VEGFR1_rcpt Family
IPR015468 CD8 alpha subunit CD8_asu Family
IPR015707 Beta-2-Microglobulin B2Microglobulin Family
IPR000920 Myelin P0 protein Myelin_P0 Family
IPR015528 Interleukin-12 beta IL-12_beta Family
IPR015513 Semaphorin 3E Semaphorin_3E Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyr_kinase_neurotrophic_rcpt_1 Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family
IPR020682 Obscurin-myosin light chain kinase Obscurin-myosin_light-ch_kin Family
IPR015631 Signalling lymphocyte activation molecule family receptors SLAM_fam_rcpts Family
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor Tyr_kinase_CSF1/PDGF_rcpt Family
IPR015621 Interleukin-1 receptor family IL-1_rcpt_fam Family
IPR004074 Interleukin-1 receptor type I/II IL-1_rcpt_I/II-typ Family
IPR000973 T-cell surface antigen CD4 Ag_CD4 Family
IPR016663 Myelin-oligodendrocyte glycoprotein Myelin-oligodendrocyte_glycop Family
IPR018250 Neuregulin Neuregulin Family
IPR016332 Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor A1B_glyco/leuk_Ig-like_rcpt Family
IPR003989 Vascular cell adhesion molecule-1 VCAM-1 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Immunoglobulin-like domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Immunoglobulin-like domain   GO:0005515 protein binding

1 Parent Features

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain

1590 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084658 Q9VAV8 Drosophila melanogaster
FBpp0289176 B7Z153 Drosophila melanogaster
FBpp0070535 Q9W4T9 Drosophila melanogaster
FBpp0304922 M9PGY4 Drosophila melanogaster
FBpp0304923 M9PBI9 Drosophila melanogaster
FBpp0304926 M9PDZ9 Drosophila melanogaster
FBpp0304930 M9PEA9 Drosophila melanogaster
FBpp0304928 M9PBJ0 Drosophila melanogaster
FBpp0304929 M9PDS8 Drosophila melanogaster
FBpp0304921 M9PDZ6 Drosophila melanogaster
FBpp0304927 M9PGZ0 Drosophila melanogaster
FBpp0301063 M9NDX0 Drosophila melanogaster
FBpp0304925 M9PEA5 Drosophila melanogaster
FBpp0304924 M9PDS3 Drosophila melanogaster
FBpp0304920 M9PEA0 Drosophila melanogaster
FBpp0300448 Q9VQW1 Drosophila melanogaster
FBpp0300447 M9NCR3 Drosophila melanogaster
FBpp0081870 Q961T8 Drosophila melanogaster
FBpp0076037 Q9VT83 Drosophila melanogaster
FBpp0303942 M9PF17 Drosophila melanogaster
FBpp0079189 Q8IPG9 Drosophila melanogaster
FBpp0086751 A1Z9G5 Drosophila melanogaster
FBpp0081202 Q8MRE6 Drosophila melanogaster
FBpp0082017 Q9VGD2 Drosophila melanogaster
FBpp0082016 Q9VGD3 Drosophila melanogaster
FBpp0082022 Q9VGD0 Drosophila melanogaster
FBpp0073587 Q7KV24 Drosophila melanogaster
FBpp0294006 Q9VK28 Drosophila melanogaster
FBpp0070537 Q08180 Drosophila melanogaster
FBpp0100143 Q09147 Drosophila melanogaster