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Protein Domain : IPR014756

Name  Immunoglobulin E-set Short Name  Ig_E-set
Type  Domain Description  The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets []. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin () and/or fibronectin type III () Ig-like protein superfamilies. Ig-like E set domains include:C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [].Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [].Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [].Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [].Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [].Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [].C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis(Bacteroides gingivalis).Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [].Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [].Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.

Publication Counts Displayer

15 Child Features

DB identifier Name Short Name Type
IPR002909 IPT domain IPT Domain
IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic K_chnl_inward-rec_Kir_cyto Domain
IPR003172 MD-2-related lipid-recognition domain ML_dom Domain
IPR024792 Rho GDP-dissociation inhibitor domain RhoGDI_domain Domain
IPR005066 Moybdenum cofactor oxidoreductase, dimerisation MoCF_OxRdtse_dimer Domain
IPR005203 Hemocyanin, C-terminal Hemocyanin_C Domain
IPR005536 Peptidase C25, Ig-like domain Peptidase_C25_Ig-like_domain Domain
IPR005102 Carbohydrate binding X2 domain Carbo-bd_X2 Domain
IPR013540 Chitinase A N-terminal ChitinaseA_N Domain
IPR015202 Domain of unknown function DUF1929 DUF1929 Domain
IPR000336 Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain Flavivir/Alphavir_Ig-like Domain
IPR015219 Glucodextranase B Glucodextran_B Domain
IPR023295 Hyaluronate lyase, beta-sheet domain Hyaluronate_lyase_beta_dom Domain
IPR014755 Copper resistance protein CopC/internalin, immunoglobulin-like Cu-Rt/internalin_Ig-like Domain
IPR014749 Herpesvirus US2, cytomegalovirus-type Herpes_US2_cytomegalovirus Domain

11 Contains

DB identifier Name Short Name Type
IPR014752 Arrestin, C-terminal Arrestin_C Domain
IPR017864 Arrestin, conserved site Arrestin_CS Conserved_site
IPR014753 Arrestin, N-terminal Arrestin_N Domain
IPR017868 Filamin/ABP280 repeat-like Filamin/ABP280_repeat-like Repeat
IPR001298 Filamin/ABP280 repeat Filamin/ABP280_rpt Repeat
IPR004193 Glycoside hydrolase, family 13, N-terminal Glyco_hydro_13_N Domain
IPR001102 Transglutaminase, N-terminal Transglutaminase_N Domain
IPR004197 Glycoside hydrolase, family 9, N-terminal, Ig-like Glyco_hydro_9_Ig-like Domain
IPR004185 Glycoside hydrolase, family 13, N-terminal Ig-like domain Glyco_hydro_13_lg-like_dom Domain
IPR015184 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV QH-AmDH_asu_dom_IV Domain
IPR015183 Quinohemoprotein amine dehydrogenase, alpha subunit domain III QH-AmDH_asu_dom_III Domain

1 Cross References

Source . Name

Subject . Primary Identifier
SSF81296 SSF IPR014756

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

12 Found In

DB identifier Name Short Name Type
IPR008015 GMP phosphodiesterase, delta subunit GMP_PDE_delta Family
IPR000698 Arrestin Arrestin Family
IPR017287 Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit Rhodop-sen_GMP-Pdiesterase_dsu Family
IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GlgB Family
IPR003523 Transcription factor COE Transcription_factor_COE Family
IPR009237 Herpesvirus US2/US3 Herpes_US2/US3 Family
IPR014438 Glucan biosynthesis, periplasmic, MdoG/D Glucan_biosyn_MdoGD Family
IPR011837 Glycogen debranching enzyme, GlgX type Glycogen_debranch_GlgX Family
IPR012768 Malto-oligosyltrehalose trehalohydrolase Trehalose_TreZ Family
IPR015171 Cyclomaltodextrinase, N-terminal Cyc-maltodext_N Domain
IPR011839 Alpha-1,6-glucosidases, pullulanase-type Pullul_strch Domain
IPR017803 Conserved hypothetical protein CHP03437, C-terminal, Solibacter usitatus CHP03437_C_SOLUE Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

793 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075282 Q9VUV9 Drosophila melanogaster
FBpp0112256 Q4V467 Drosophila melanogaster
FBpp0112257 A8JQV1 Drosophila melanogaster
FBpp0079156 Q8IPH0 Drosophila melanogaster
FBpp0079155 Q9VLU2 Drosophila melanogaster
FBpp0291497 Q7K2W6 Drosophila melanogaster
FBpp0290793 P98149 Drosophila melanogaster
FBpp0081808 Q9VGU7 Drosophila melanogaster
FBpp0071397 Q9W2V2 Drosophila melanogaster
FBpp0088363 Q24388 Drosophila melanogaster
FBpp0291569 Q9W204 Drosophila melanogaster
FBpp0080583 P15372 Drosophila melanogaster
FBpp0303746 M9PD73 Drosophila melanogaster
FBpp0303748 M9PDF6 Drosophila melanogaster
FBpp0303747 M9PDR0 Drosophila melanogaster
FBpp0080795 Q9VIT9 Drosophila melanogaster
FBpp0073484 P11995 Drosophila melanogaster
FBpp0074426 Q9VWP4 Drosophila melanogaster
FBpp0081801 Q9VGU4 Drosophila melanogaster
FBpp0074665 Q9VW59 Drosophila melanogaster
FBpp0080559 E1JHK3 Drosophila melanogaster
FBpp0080560 P15330 Drosophila melanogaster
FBpp0076558 Q9VS57 Drosophila melanogaster
FBpp0290792 E1JHK2 Drosophila melanogaster
FBpp0075491 Q04691 Drosophila melanogaster
FBpp0081270 Q9VHZ9 Drosophila melanogaster
FBpp0088288 Q0KIF1 Drosophila melanogaster
FBpp0088287 Q9V491 Drosophila melanogaster
FBpp0080261 P28159 Drosophila melanogaster
FBpp0071830 Q8MME5 Drosophila melanogaster