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Protein Domain : IPR013783

Name  Immunoglobulin-like fold Short Name  Ig-like_fold
Type  Domain Description  This entry represents domains with an immunoglobulin-like (Ig-like) fold, which consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals, occurring in a variety of different proteins. These domains are often involved in interactions, commonly with other Ig-like domains via their beta-sheets [, , , ]. Domains within this fold-family share the same structure, but can diverge with respect to their sequence. Based on sequence, Ig-like domains can be classified as V-set domains (antibody variable domain-like), C1-set domains (antibody constant domain-like), C2-set domains, and I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example, in the human T-cell receptor antigen CD2, domain 1 (D1) is a V-set domain, while domain 2 (D2) is a C2-set domain, both domains having the same Ig-like fold [].Domains with an Ig-like fold can be found in many, diverse proteins in addition to immunoglobulin molecules. For example, Ig-like domains occur in several different types of receptors (such as various T-cell antigen receptors), several cell adhesion molecules, MHC class I and II antigens, as well as the hemolymph protein hemolin, and the muscle proteins titin, telokin and twitchin.

Publication Counts Displayer

4 Child Features

DB identifier Name Short Name Type
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR003961 Fibronectin, type III Fibronectin_type3 Domain
IPR001102 Transglutaminase, N-terminal Transglutaminase_N Domain
IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain NK_rcpt_2B4_Ig_dom Domain

18 Contains

DB identifier Name Short Name Type
IPR002909 IPT domain IPT Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR013106 Immunoglobulin V-set domain Ig_V-set Domain
IPR013151 Immunoglobulin Immunoglobulin Domain
IPR017868 Filamin/ABP280 repeat-like Filamin/ABP280_repeat-like Repeat
IPR001298 Filamin/ABP280 repeat Filamin/ABP280_rpt Repeat
IPR003006 Immunoglobulin/major histocompatibility complex, conserved site Ig/MHC_CS Conserved_site
IPR004193 Glycoside hydrolase, family 13, N-terminal Glyco_hydro_13_N Domain
IPR015370 Domain of unknown function DUF1968 DUF1968 Domain
IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal ICAM_VCAM_N Domain
IPR003988 Intercellular adhesion molecule ICAM Domain
IPR013768 Intercellular adhesion molecule, N-terminal ICAM_N Domain
IPR008424 Immunoglobulin C2-set Ig_C2-set Domain
IPR004197 Glycoside hydrolase, family 9, N-terminal, Ig-like Glyco_hydro_9_Ig-like Domain
IPR005536 Peptidase C25, Ig-like domain Peptidase_C25_Ig-like_domain Domain
IPR005102 Carbohydrate binding X2 domain Carbo-bd_X2 Domain
IPR015169 Adhesion molecule, immunoglobulin-like Adhes-Ig-like Domain
IPR015274 CD4, extracellular CD4-extracel Domain

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

39 Found In

DB identifier Name Short Name Type
IPR016247 Tyrosine-protein kinase, receptor ROR Tyr_kinase_rcpt_ROR Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR008465 Dystroglycan DAG1 Family
IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GlgB Family
IPR000451 NF-kappa-B/Rel/Dorsal NF_Rel_Dor Family
IPR011363 Dorsal protein Dorsal Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR008366 Nuclear factor of activated T cells (NFAT) NFAT Family
IPR015646 Nuclear factor of activated T-cells 5 NFAT5 Family
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR2_rcpt Family
IPR015468 CD8 alpha subunit CD8_asu Family
IPR015707 Beta-2-Microglobulin B2Microglobulin Family
IPR015485 CD3 signalling complex delta subunit CD3D Family
IPR015484 CD3 protein, epsilon/gamma/delta subunit CD3_esu/gsu/dsu Family
IPR015528 Interleukin-12 beta IL-12_beta Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyr_kinase_neurotrophic_rcpt_1 Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family
IPR015653 Intercellular adhesion molecule 2 ICAM2 Family
IPR015647 Nuclear factor of activated T-cells 1 NFAT1 Family
IPR015632 T-cell surface antigen CD2 CD2 Family
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor Tyr_kinase_CSF1/PDGF_rcpt Family
IPR011838 Pullulanase, extracellular Pullulan_Gpos Domain
IPR015621 Interleukin-1 receptor family IL-1_rcpt_fam Family
IPR015714 Lymphocyte function associated antigen 3 Lymphocyte_func-assoc_Ag_3 Family
IPR008291 Glucoamylase, starch-binding Glucoamylase_SBD Family
IPR011840 Pullulanase, type I PulA_typeI Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

2444 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084658 Q9VAV8 Drosophila melanogaster
FBpp0293057 M9MRI4 Drosophila melanogaster
FBpp0079685 Q86P21 Drosophila melanogaster
FBpp0289176 B7Z153 Drosophila melanogaster
FBpp0070535 Q9W4T9 Drosophila melanogaster
FBpp0304922 M9PGY4 Drosophila melanogaster
FBpp0304923 M9PBI9 Drosophila melanogaster
FBpp0304926 M9PDZ9 Drosophila melanogaster
FBpp0304930 M9PEA9 Drosophila melanogaster
FBpp0304928 M9PBJ0 Drosophila melanogaster
FBpp0304929 M9PDS8 Drosophila melanogaster
FBpp0304921 M9PDZ6 Drosophila melanogaster
FBpp0304927 M9PGZ0 Drosophila melanogaster
FBpp0301063 M9NDX0 Drosophila melanogaster
FBpp0304925 M9PEA5 Drosophila melanogaster
FBpp0304924 M9PDS3 Drosophila melanogaster
FBpp0304920 M9PEA0 Drosophila melanogaster
FBpp0300448 Q9VQW1 Drosophila melanogaster
FBpp0300447 M9NCR3 Drosophila melanogaster
FBpp0081870 Q961T8 Drosophila melanogaster
FBpp0076037 Q9VT83 Drosophila melanogaster
FBpp0303942 M9PF17 Drosophila melanogaster
FBpp0079189 Q8IPG9 Drosophila melanogaster
FBpp0074813 Q9VVV4 Drosophila melanogaster
FBpp0086751 A1Z9G5 Drosophila melanogaster
FBpp0081202 Q8MRE6 Drosophila melanogaster
FBpp0079156 Q8IPH0 Drosophila melanogaster
FBpp0079155 Q9VLU2 Drosophila melanogaster
FBpp0293362 Q86BP0 Drosophila melanogaster
FBpp0082017 Q9VGD2 Drosophila melanogaster