modENCODE |  Help |  blog

Protein Domain : IPR002931

Name  Transglutaminase-like Short Name  Transglutaminase-like
Type  Domain Description  This domain is found in many proteins known to have transglutaminase activity, i.e. which cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the epsilon-amino group of peptide-bound lysine, resulting in a epsilon-(gamma-glutamyl)lysine isopeptide bond. Tranglutaminases have been found in a diverse range of species, from bacteria through to mammals. The enzymes require calcium binding and their activity leads to post-translational modification of proteins through acyl-transfer reactions, involving peptidyl glutamine residues as acyl donors and a variety of primary amines as acyl acceptors, with the generation of proteinase resistant isopeptide bonds []. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase, the human blood clotting factor XIIIa' []. On the basis of the experimentally demonstrated activity of the Methanobacterium phage psiM2pseudomurein endoisopeptidase [], it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease [].A subunit of plasma Factor XIII revealed that each Factor XIIIA subunit is composed of four domains (termed N-terminal beta-sandwich, core domain (containing the catalytic and the regulatory sites), and C-terminal beta-barrels 1 and 2) and that two monomers assemble into the native dimer through the surfaces in domains 1 and 2, in opposite orientation. This organisation in four domains is highly conserved during evolution among transglutaminase isoforms [].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR013808 Transglutaminase, conserved site Transglutaminase_CS Conserved_site

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF01841 PFAM IPR002931
SM00460 SMART IPR002931
G3DSA:3.90.260.10 GENE3D IPR002931

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR017017 Uncharacterised conserved protein UCP033622, transglutaminase-like, CPE1922 UCP033622_transglutaminase Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

24 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079156 Q8IPH0 Drosophila melanogaster
FBpp0079155 Q9VLU2 Drosophila melanogaster
FBpp0110094 Q4V516 Drosophila melanogaster
FBpp0085325 Q7KRR5 Drosophila melanogaster
FBpp0280740 Q29LV1 Drosophila pseudoobscura
FBpp0276277 Q28YQ7 Drosophila pseudoobscura
FBpp0167130 B4KEB5 Drosophila mojavensis
FBpp0169170 B4KSC7 Drosophila mojavensis
FBpp0232101 B4LSK9 Drosophila virilis
FBpp0232282 B4MDY1 Drosophila virilis
FBpp0263735 B4NWC1 Drosophila yakuba
FBpp0265680 B4NYW0 Drosophila yakuba
NGLY1_CAEBR Q5WNE3 Caenorhabditis briggsae
A8WN69_CAEBR A8WN69 Caenorhabditis briggsae
H2VRF3_CAEJA H2VRF3 Caenorhabditis japonica
H2W8A4_CAEJA H2W8A4 Caenorhabditis japonica
G0NIJ2_CAEBE G0NIJ2 Caenorhabditis brenneri
G0NY82_CAEBE G0NY82 Caenorhabditis brenneri
NGLY1_CAEEL Q9TW67 Caenorhabditis elegans
G5EF51_CAEEL G5EF51 Caenorhabditis elegans
NGLY1_DROME-2 Q7KRR5-2 Drosophila melanogaster
D0IQ93_DROME D0IQ93 Drosophila melanogaster
E3NHL0_CAERE E3NHL0 Caenorhabditis remanei
E3LGV9_CAERE E3LGV9 Caenorhabditis remanei