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Protein Domain : IPR002198

Name  Short-chain dehydrogenase/reductase SDR Short Name  DH_sc/Rdtase_SDR
Type  Family Description  The short-chain dehydrogenases/reductases family (SDR) []is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called [, , ]'insect-type', or 'short-chain' alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains [], the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains [].

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR002424 Alcohol dehydrogenase, insect-type ADH_insect Family
IPR027533 Very-long-chain 3-oxoacyl-CoA reductase, fungal 3_ketoreductase_fungal Family
IPR027052 Dehydrogenase/reductase SDR member 2 DHRS2 Family

2 Contains

DB identifier Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site Sc_DH/Rdtase_CS Conserved_site

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00106 PFAM IPR002198
PIRSF000126 PIRSF IPR002198
PR00080 PRINTS IPR002198

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Short-chain dehydrogenase/reductase SDR   GO:0016491 oxidoreductase activity
Short-chain dehydrogenase/reductase SDR   GO:0008152 metabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Short-chain dehydrogenase/reductase SDR   GO:0016491 oxidoreductase activity
Short-chain dehydrogenase/reductase SDR   GO:0008152 metabolic process

1 Parent Features

DB identifier Name Short Name Type
IPR002347 Glucose/ribitol dehydrogenase Glc/ribitol_DH Family

695 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087993 Q7JUS1 Drosophila melanogaster
FBpp0070179 Q9U1L2 Drosophila melanogaster
FBpp0071131 Q9W3H4 Drosophila melanogaster
FBpp0309547 Q9VKB8 Drosophila melanogaster
FBpp0078356 Q8SX57 Drosophila melanogaster
FBpp0087129 Q7K3N4 Drosophila melanogaster
FBpp0300159 Q9I7R3 Drosophila melanogaster
FBpp0099972 Q9VSU6 Drosophila melanogaster
FBpp0077075 Q9VR28 Drosophila melanogaster
FBpp0070101 Q9W5H1 Drosophila melanogaster
FBpp0099544 P91615 Drosophila melanogaster
FBpp0075142 Q9VV47 Drosophila melanogaster
FBpp0073988 Q9VXJ0 Drosophila melanogaster
FBpp0083009 Q8SZ46 Drosophila melanogaster
FBpp0080479 Q8SX47 Drosophila melanogaster
FBpp0083499 Q9VDC0 Drosophila melanogaster
FBpp0073324 Q9VZ19 Drosophila melanogaster
FBpp0087996 Q7JYX2 Drosophila melanogaster
FBpp0078386 Q9VNF4 Drosophila melanogaster
FBpp0084585 Q9VB10 Drosophila melanogaster
FBpp0077342 Q9VQL6 Drosophila melanogaster
FBpp0077552 Q9VQ39 Drosophila melanogaster
FBpp0087995 Q8MZG9 Drosophila melanogaster
FBpp0078385 Q8IPP8 Drosophila melanogaster
FBpp0079172 Q9VLU5 Drosophila melanogaster
FBpp0085611 Q7K0F7 Drosophila melanogaster
FBpp0083754 Q9VCR9 Drosophila melanogaster
FBpp0075184 Q9VV42 Drosophila melanogaster
FBpp0075185 Q8IQN8 Drosophila melanogaster
FBpp0083002 Q8T0J5 Drosophila melanogaster