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Protein Domain : IPR012336

Name  Thioredoxin-like fold Short Name  Thioredoxin-like_fold
Type  Domain Description  Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system []. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain domains with a thioredoxin-like fold include:Arsenate reductase (ArsC) []Calsequestrin (contains three tandem repeats of this fold) []Circadian oscillation regulator KaiB []Disulphide bond isomerase DsbC and DsbG (C-terminal domain) [, ]Disulphide bond facilitator DsbA (contains an alpha-helical insertion) []Endoplasmic reticulum protein ERP29 (N-terminal domain) []Glutathione S-transferase (GST) (N-terminal domain) []Mitochondrial ribosomal protein L51/S25/CI-B8 domain (variable positions for Cys residues in active site) []Phosducin []Protein disulphide isomerase (PDI) (contains two tandem repeats of this fold) []Glutathione peroxidase-like enzymes []Selenoprotein W-related []SH3-binding glutamic acid-rich protein like (SH3BGR) (lacks both conserved Cys residues) []Spliceosomal protein U5-15Kd []Thioltransferases, including thioredoxin [], glutaredoxon [], hybrid peroxiredoxin hyPrx5 []Thioredoxin-like 2Fe-2S ferredoxin []

Publication Counts Displayer

7 Child Features

DB identifier Name Short Name Type
IPR004045 Glutathione S-transferase, N-terminal Glutathione_S-Trfase_N Domain
IPR013766 Thioredoxin domain Thioredoxin_domain Domain
IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant AhpC/TSA Domain
IPR024253 Phosducin, thioredoxin-like domain Phosducin_thioredoxin-like_dom Domain
IPR013740 Redoxin Redoxin Domain
IPR011649 KaiB domain KaiB_domain Domain
IPR012941 Phenol hydroxylase, C-terminal dimerisation Phe_hydrox_C_dim Domain

8 Contains

DB identifier Name Short Name Type
IPR017937 Thioredoxin, conserved site Thioredoxin_CS Conserved_site
IPR002109 Glutaredoxin Glutaredoxin Domain
IPR004879 Domain of unknown function DUF255 DUF255 Domain
IPR011767 Glutaredoxin active site GLR_AS Active_site
IPR019479 Peroxiredoxin, C-terminal Peroxiredoxin_C Domain
IPR018219 Antioxidant Tpx conserved site Antioxidant_Tpx_CS Conserved_site
IPR018233 Calsequestrin, conserved site Calsequestrin_CS Conserved_site
IPR008261 Iodothyronine deiodinase, active site Iodothyronine_deiodinase_AS Active_site

6 Cross References

Source . Name

Subject . Primary Identifier
PF13098 PFAM IPR012336
PF13192 PFAM IPR012336
PF13462 PFAM IPR012336
PS51352 PROFILE IPR012336
SSF52833 SSF IPR012336

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

13 Found In

DB identifier Name Short Name Type
IPR014440 HCCA isomerase/glutathione S-transferase kappa HCCAis_GSTk Family
IPR012883 ERp29, N-terminal ERp29_N Domain
IPR021170 DnaJ homolog, subfamily C DnaJ_homolog_subfam-C Family
IPR017346 Uncharacterised conserved protein UCP037991, UAS/UBX UCP037991_UAS/UBX Family
IPR003083 S-crystallin S-crystallin Family
IPR017167 Uncharacterised conserved protein UCP037291, glutaredoxin-related UCP037291_glutaredoxin-rel Family
IPR009737 Sucraseferredoxin-like Suc_Fer-like Family
IPR010350 Protein of unknown function DUF942, thioredoxin-like DUF942_thioredox Family
IPR012863 Protein of unknown function DUF1636 DUF1636 Family
IPR014111 Type IV conjugative transfer system protein TraF T4SS_TraF Family
IPR014109 Type-F conjugative transfer system pilin assembly thiol-disulphide isomerase TrbB Thiol-disulphide_isomerase_rbB Family
IPR016639 Glutathione S-transferase (GST) GST Family
IPR010296 Protein of unknown function DUF899, thioredoxin-like DUF899_thioredox Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1546 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085856 A1ZB72 Drosophila melanogaster
FBpp0076349 Q9VSL3 Drosophila melanogaster
FBpp0085852 A1ZB68 Drosophila melanogaster
FBpp0085851 Q7JYZ9 Drosophila melanogaster
FBpp0085857 A1ZB73 Drosophila melanogaster
FBpp0085853 A1ZB69 Drosophila melanogaster
FBpp0100079 Q960M4 Drosophila melanogaster
FBpp0075794 Q8MR62 Drosophila melanogaster
FBpp0079233 Q8SY53 Drosophila melanogaster
FBpp0099646 P41043 Drosophila melanogaster
FBpp0074949 Q9VVJ7 Drosophila melanogaster
FBpp0083547 Q9VD62 Drosophila melanogaster
FBpp0292398 Q9VYV3 Drosophila melanogaster
FBpp0305170 M9PGX2 Drosophila melanogaster
FBpp0073609 Q8MRM0 Drosophila melanogaster
FBpp0081522 Q9VHD3 Drosophila melanogaster
FBpp0085850 Q7KK90 Drosophila melanogaster
FBpp0073666 Q9VY78 Drosophila melanogaster
FBpp0070503 Q9W4S1 Drosophila melanogaster
FBpp0085660 Q7JW12 Drosophila melanogaster
FBpp0087548 Q7K0B6 Drosophila melanogaster
FBpp0087356 A1Z892 Drosophila melanogaster
FBpp0085854 A1ZB70 Drosophila melanogaster
FBpp0085855 A1ZB71 Drosophila melanogaster
FBpp0085905 Q4V6J1 Drosophila melanogaster
FBpp0070484 Q9U1K7 Drosophila melanogaster
FBpp0085858 Q7K8X7 Drosophila melanogaster
FBpp0071993 Q9W1L1 Drosophila melanogaster
FBpp0085780 Q4V6H2 Drosophila melanogaster
FBpp0113057 B7Z0S9 Drosophila melanogaster