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Protein Domain : IPR013026

Name  Tetratricopeptide repeat-containing domain Short Name  TPR-contain_dom
Type  Domain Description  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs canbe dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have beenidentified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation,transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed thatTPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within asingle TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface iscontributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B.

Publication Counts Displayer

0 Child Features

6 Contains

DB identifier Name Short Name Type
IPR013105 Tetratricopeptide TPR2 TPR_2 Repeat
IPR001440 Tetratricopeptide TPR1 TPR_1 Repeat
IPR019544 Tetratricopeptide, SHNi-TPR domain Tetratricopeptide_SHNi-TPR_dom Domain
IPR015792 Kinesin light chain repeat Kinesin_light_repeat Repeat
IPR011717 Tetratricopeptide TPR-4 TPR-4 Repeat
IPR011716 Tetratricopeptide TPR-3 TPR-3 Repeat

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS50293 PROFILE IPR013026

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

17 Found In

DB identifier Name Short Name Type
IPR011990 Tetratricopeptide-like helical TPR-like_helical Domain
IPR021183 N-terminal acetyltransferase A, auxiliary subunit NatA_aux_su Family
IPR002151 Kinesin light chain Kinesin_light Family
IPR011236 Serine/threonine protein phosphatase 5 Ser/Thr_PPase_5 Family
IPR001237 43kDa postsynaptic protein Postsynaptic Family
IPR005415 Type III secretion system, low calcium response, chaperone LcrH/SycD T3SS_Ca_resp_chp_LcrH/SycD Family
IPR016379 Type III secretion system, low calcium response, chaperone LcrH/SycD, subgroup T3SS_Ca_resp_chp_LcrH/SycD_sub Family
IPR005687 Mitochondrial outer membrane translocase complex, subunit Tom70 Tom70 Family
IPR003921 Cellulose synthase, subunit C Cell_synth_C Family
IPR016684 Type III secretion system chaperone, YscY T3SS_YscY Family
IPR016931 Uncharacterised conserved protein UCP029658, TPR UCP029658_TPR Family
IPR014562 Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing UCP030959_TPR_rpt-cont Family
IPR014162 Tol-Pal system, YbgF Tol-Pal_YbgF Domain
IPR014266 PEP-CTERM system TPR-repeat lipoprotein, putative PEP-CTERM_TPR_lipo Family
IPR013360 Pilus biogenesis/stability type IV, PilW Pilus_4_PilW Family
IPR014596 Uncharacterised conserved protein UCP035836 UCP035836 Family
IPR014460 Signal transduction response regulator, predicted, VieB Sig_transdc_resp-reg_VieB Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetratricopeptide repeat-containing domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetratricopeptide repeat-containing domain   GO:0005515 protein binding

0 Parent Features

716 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074480 Q9VWI2 Drosophila melanogaster
FBpp0070351 O46085 Drosophila melanogaster
FBpp0070352 Q7KW08 Drosophila melanogaster
FBpp0081606 Q9VH81 Drosophila melanogaster
FBpp0080894 Q9I7L8 Drosophila melanogaster
FBpp0083769 Q9VCN6 Drosophila melanogaster
FBpp0110159 Q0KHY6 Drosophila melanogaster
FBpp0085046 Q8IMI2 Drosophila melanogaster
FBpp0078887 Q8SWV6 Drosophila melanogaster
FBpp0085923 Q7K7W5 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0307598 M9PFS0 Drosophila melanogaster
FBpp0087297 A1Z8E9 Drosophila melanogaster
FBpp0070906 Q9W3Y7 Drosophila melanogaster
FBpp0080535 Q9VJD4 Drosophila melanogaster
FBpp0079893 Q9VKC8 Drosophila melanogaster
FBpp0085033 Q9VA50 Drosophila melanogaster
FBpp0081805 Q9VGU5 Drosophila melanogaster
FBpp0073411 Q9VYT2 Drosophila melanogaster
FBpp0303439 Q8IR85 Drosophila melanogaster
FBpp0080720 Q8SYD0 Drosophila melanogaster
FBpp0085047 Q9VA61 Drosophila melanogaster
FBpp0082818 Q9VEQ1 Drosophila melanogaster
FBpp0085842 Q7K3D4 Drosophila melanogaster
FBpp0082819 Q9VEQ2 Drosophila melanogaster
FBpp0082765 Q9VEV3 Drosophila melanogaster
FBpp0082652 Q8IND4 Drosophila melanogaster
FBpp0084188 Q9VBU7 Drosophila melanogaster
FBpp0082149 Q9VG61 Drosophila melanogaster
FBpp0075788 Q9VTS8 Drosophila melanogaster