modENCODE |  Help |  blog

Protein Domain : IPR011991

Name  Winged helix-turn-helix DNA-binding domain Short Name  WHTH_DNA-bd_dom
Type  Domain Description  Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif, where the "wings", or loops, are small beta-sheets. The winged helix motif consists of two wings (W1, W2), three alpha helices (H1, H2, H3) and three beta-sheets (S1, S2, S3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 []. The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA, while the wings make different DNA contacts, often with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions.Many different proteins with diverse biological functions contain a winged helix DNA-binding domain, including transcriptional repressors such as biotin repressor, LexA repressor and the arginine repressor []; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation, heat-shock transcription factor, and the general transcription factors TFIIE and TFIIF [, ]; helicases such as RuvB that promotes branch migration at the Holliday junction, and CDC6 in the pre-replication complex [, ]; endonucleases such as FokI and TnsA []; histones; and Mu transposase, where the flexible wing of the enhancer-binding domain is essential for efficient transposition [].

Publication Counts Displayer

36 Child Features

DB identifier Name Short Name Type
IPR000591 DEP domain DEP_dom Domain
IPR001766 Transcription factor, fork head TF_fork_head Domain
IPR019559 Cullin protein, neddylation domain Cullin_neddylation_domain Domain
IPR000418 Ets domain Ets_dom Domain
IPR003316 Transcription factor E2F/dimerisation partner (TDP) E2F_TDP Domain
IPR005818 Linker histone H1/H5, domain H15 Histone_H1/H5_H15 Domain
IPR006630 RNA-binding protein Lupus La Lupus_La_RNA-bd Domain
IPR000232 Heat shock factor (HSF)-type, DNA-binding HSF_DNA-bd Domain
IPR003150 DNA-binding RFX-type winged-helix domain DNA-bd_RFX Domain
IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding MethylDNA_cys_MeTrfase_DNA-bd Domain
IPR015163 CDC6, C-terminal domain Cdc6_C_dom Domain
IPR013196 Helix-turn-helix, type 11 HTH_11 Domain
IPR016032 Signal transduction response regulator, C-terminal effector Sig_transdc_resp-reg_C-effctor Domain
IPR000524 Transcription regulator HTH, GntR Tscrpt_reg_HTH_GntR Domain
IPR000847 Transcription regulator HTH, LysR Tscrpt_reg_HTH_LysR Domain
IPR002577 Helix-turn-helix, HxlR type HTH_HxlR Domain
IPR001845 HTH ArsR-type DNA-binding domain HTH_ArsR_DNA-bd_dom Domain
IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA) dsRNA_A_deaminase Domain
IPR020900 Arginine repressor, DNA-binding domain Arg_repress_DNA-bd Domain
IPR001346 Interferon regulatory factor DNA-binding domain Interferon_reg_fact_DNA-bd_dom Domain
IPR000485 AsnC-type HTH domain AsnC-type_HTH_dom Domain
IPR005561 ANTAR domain ANTAR Domain
IPR027395 Winged helix DNA-binding domain WH_DNA-bd_dom Domain
IPR015191 Translation elongation factor SelB, winged helix, type 3 Elong_fac_SelB-wing-hlx_typ-3 Domain
IPR009718 Rex DNA-binding, C-terminal Rex_DNA-bd_C Domain
IPR006199 LexA repressor, DNA-binding domain LexA_DNA-bd_dom Domain
IPR002831 Transcription regulator TrmB, N-terminal Tscrpt_reg_TrmB_N Domain
IPR004409 Biotin operon repressor, helix-turn-helix domain Biotin_operon_repress_HTH Domain
IPR015265 Bacterial purine repressor, N-terminal PuR_N Domain
IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal DNA_helicase_Holl-junc_RuvB_C Domain

15 Contains

DB identifier Name Short Name Type
IPR018122 Transcription factor, fork head, conserved site TF_fork_head_CS Conserved_site
IPR016157 Cullin, conserved site Cullin_CS Conserved_site
IPR017919 Transcription factor TFE/TFIIEalpha HTH domain TFIIE/TFIIEa_HTH Domain
IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site MethylDNA_cys_MeTrfase_AS Active_site
IPR013196 Helix-turn-helix, type 11 HTH_11 Domain
IPR013324 RNA polymerase sigma factor, region 3/4 RNA_pol_sigma_r3_r4 Domain
IPR001867 Signal transduction response regulator, C-terminal Sig_transdc_resp-reg_C Domain
IPR019817 Interferon regulatory factor, conserved site Interferon_reg_fac_CS Conserved_site
IPR019885 Transcription regulator HTH, AsnC-type, conserved site Tscrpt_reg_HTH_AsnC-type_CS Conserved_site
IPR007630 RNA polymerase sigma-70 region 4 RNA_pol_sigma70_r4 Domain
IPR015189 Translation elongation factor SelB, winged helix, type 1 Elong_fac_SelB-wing-hlx_typ-1 Domain
IPR018334 ArsR-type transcription regulator, HTH motif ArsR_HTH Conserved_site
IPR018335 Transcription regulator HTH, Crp-type, conserved site Tscrpt_reg_HTH_Crp-type_CS Conserved_site
IPR001808 Transcription regulator HTH, Crp Tscrpt_reg_HTH_Crp Domain
IPR007624 RNA polymerase sigma-70 region 3 RNA_pol_sigma70_r3 Domain

2 Cross References

Source . Name

Subject . Primary Identifier
PF13412 PFAM IPR011991

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

67 Found In

DB identifier Name Short Name Type
IPR000717 Proteasome component (PCI) domain PCI_dom Domain
IPR009374 Eukaryotic translation initiation factor 3 subunit K eIF3k Family
IPR008339 Dishevelled family Dishevelled_fam Family
IPR014646 Replication protein A, subunit RPA32 RPA32 Family
IPR014892 Replication protein A, C-terminal RPA_C Domain
IPR005819 Histone H5 Histone_H5 Family
IPR002717 MOZ/SAS-like protein MOZ_SAS Domain
IPR016656 Transcription initiation factor TFIIE, beta subunit TFIIE-bsu Family
IPR002853 Transcription factor TFIIE, alpha subunit TFIIE_asu Family
IPR003196 Transcription initiation factor IIF, beta subunit TFIIF_beta Family
IPR008851 Transcription initiation factor IIF, alpha subunit TFIIF-alpha Family
IPR004085 DNA topoisomerase VI, subunit A TopoVI_A Family
IPR016640 Transcription initiation factor IIF, beta subunit, subgroup TFIIF-beta_subgr Family
IPR002571 Heat-inducible transcription repressor HrcA HrcA Family
IPR014284 RNA polymerase sigma-70 like domain RNA_pol_sigma-70_dom Domain
IPR001669 Arginine repressor Arg_repress Family
IPR019888 Transcription regulator AsnC-type Tscrpt_reg_AsnC-typ Family
IPR012761 RNA polymerase sigma factor RpoS RNA_pol_sigma_RpoS Family
IPR016262 RNA polymerase sigma factor, SigB/SigC/SigD, plastid RNA_pol_sigma_SigB/C/D_plastid Family
IPR017848 RNA polymerase sigma factor, RpoD-like, cyanobacteria RNA_pol_sigma_RpoD_cyanobac Family
IPR010906 Bacteriophage lambda, Nu1, terminase small subunit Phage_lambda_Nu1_terminase-ssu Family
IPR003314 Transposase MuA/Repressor CI, DNA-binding MuA/CI_DNA-bd Domain
IPR006200 LexA repressor LexA Family
IPR020890 Transcription regulator HTH, HdfR Tscrpt_reg_HTH_HdfR Family
IPR019941 Transcription regulator LuxR, chaperone HchA-associated Tscrpt_reg_LuxR_HchA-assoc Family
IPR016481 Transcription factor TFE, archaea TF_E_archaea Family
IPR005234 Chromosome segregation/condensation protein ScpB ScpB_csome_segregation Family
IPR001367 Iron dependent repressor-like, metal binding and dimerisation domain Fe_dep_repressor Domain
IPR022689 Iron dependent repressor, diptheria toxin type Fe_dep_repressor_HTH_DtxR Domain
IPR000525 Initiator Rep protein Initiator_Rep_prot Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1457 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081195 O76339 Drosophila melanogaster
FBpp0091054 Q4ABD8 Drosophila melanogaster
FBpp0091089 P02255 Drosophila melanogaster
FBpp0086013 A1ZAX1 Drosophila melanogaster
FBpp0099747 Q59DP0 Drosophila melanogaster
FBpp0099749 Q59DN8 Drosophila melanogaster
FBpp0099750 Q59DN7 Drosophila melanogaster
FBpp0099751 Q59DN9 Drosophila melanogaster
FBpp0072065 Q9W1E5 Drosophila melanogaster
FBpp0290778 D1YSG9 Drosophila melanogaster
FBpp0088523 O96838 Drosophila melanogaster
FBpp0304899 M9PI07 Drosophila melanogaster
FBpp0304900 M9PC64 Drosophila melanogaster
FBpp0304898 M9PF47 Drosophila melanogaster
FBpp0291179 Q0E8F8 Drosophila melanogaster
FBpp0290009 Q8IQE9 Drosophila melanogaster
FBpp0307179 Q9W4Q1 Drosophila melanogaster
FBpp0085442 A1Z6M0 Drosophila melanogaster
FBpp0076762 P29774 Drosophila melanogaster
FBpp0074966 E2QCT0 Drosophila melanogaster
FBpp0072159 Q9W1A9 Drosophila melanogaster
FBpp0083905 Q7KS38 Drosophila melanogaster
FBpp0081715 Q9XTP7 Drosophila melanogaster
FBpp0079882 P06601 Drosophila melanogaster
FBpp0099525 Q9VTX7 Drosophila melanogaster
FBpp0091101 Q4AB54 Drosophila melanogaster
FBpp0099768 Q59E27 Drosophila melanogaster
FBpp0099809 Q59DQ1 Drosophila melanogaster
FBpp0099810 Q59DQ2 Drosophila melanogaster
FBpp0091080 Q4AB94 Drosophila melanogaster