modENCODE |  Help |  blog

Protein Domain : IPR000717

Name  Proteasome component (PCI) domain Short Name  PCI_dom
Type  Domain Description  A homology domain of unclear function, occurs in the C-terminal region of severalregulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [].Apparently, all of the characterised proteins containing PCI domains are parts of largermulti-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2), Rpn5, Rpn6, Rpn7and Rpn9 []; mammalian proteasome regulatory components p55, p58 and p44.5, and translationinitiation factor 3 complex subunits p110 and INT6 [, ]; ArabidopsisCOP9 and FUS6/COP11 []; mammalian G-protein pathway suppressor GPS1, and severaluncharacterised ORFs from plant, nematodes and mammals. The complete homology domain comprisesapprox. 200 residues, the highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF01399 PFAM IPR000717
SM00088 SMART IPR000717

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR016650 Eukaryotic translation initiation factor 3 subunit E eIF3e Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Proteasome component (PCI) domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Proteasome component (PCI) domain   GO:0005515 protein binding

0 Parent Features

164 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086013 A1ZAX1 Drosophila melanogaster
FBpp0087821 Q9V4S8 Drosophila melanogaster
FBpp0074841 Q9VVU5 Drosophila melanogaster
FBpp0089195 Q94899 Drosophila melanogaster
FBpp0083687 Q9V3G7 Drosophila melanogaster
FBpp0086604 Q7KLV9 Drosophila melanogaster
FBpp0087935 Q9V345 Drosophila melanogaster
FBpp0083861 Q7KMP8 Drosophila melanogaster
FBpp0077927 Q8SYG2 Drosophila melanogaster
FBpp0078278 Q9V3Z4 Drosophila melanogaster
FBpp0075104 O77410 Drosophila melanogaster
FBpp0086705 Q7JVI3 Drosophila melanogaster
FBpp0078584 Q9VN25 Drosophila melanogaster
FBpp0075833 Q9VTL1 Drosophila melanogaster
FBpp0291495 P25161 Drosophila melanogaster
FBpp0277400 Q292J2 Drosophila pseudoobscura
FBpp0282164 B5DYB0 Drosophila pseudoobscura
FBpp0274175 Q2LZ67 Drosophila pseudoobscura
FBpp0274880 Q2M153 Drosophila pseudoobscura
FBpp0276360 Q28Z41 Drosophila pseudoobscura
FBpp0276783 B5E078 Drosophila pseudoobscura
FBpp0276999 Q292F0 Drosophila pseudoobscura
FBpp0277681 Q290Y3 Drosophila pseudoobscura
FBpp0279146 Q29PI4 Drosophila pseudoobscura
FBpp0283940 Q298U4 Drosophila pseudoobscura
FBpp0284180 Q297K5 Drosophila pseudoobscura
FBpp0285645 Q29JS0 Drosophila pseudoobscura
FBpp0286137 Q29DK4 Drosophila pseudoobscura
FBpp0286544 Q29EX2 Drosophila pseudoobscura
FBpp0284614 Q295G5 Drosophila pseudoobscura