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Protein Domain : IPR014721

Name  Ribosomal protein S5 domain 2-type fold, subgroup Short Name  Ribosomal_S5_D2-typ_fold_subgr
Type  Domain Description  Domain 2 of the ribosomal protein S5 has a left-handed beta-alpha-beta fold that is found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this beta-alpha-beta fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) [].Ribonuclease P protein (RNase P) [].DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) [].GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase (), homoserine kinase (), and mevalonate kinase ()) [, ].Caenorhabditis elegansearly switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) [].

Publication Counts Displayer

6 Child Features

DB identifier Name Short Name Type
IPR005517 Translation elongation factor EFG/EF2, domain IV Transl_elong_EFG/EF2_IV Domain
IPR005324 Ribosomal protein S5, C-terminal Ribosomal_S5_C Domain
IPR015192 Switch protein XOL-1, N-terminal Xol-1_N Domain
IPR013507 DNA mismatch repair protein, C-terminal DNA_mismatch_repair_C Domain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 Topo_IIA_bsu_dom2 Domain
IPR015320 DNA topoisomerase VI, subunit B, transducer TopoVI_B_transducer Domain

6 Contains

DB identifier Name Short Name Type
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR020574 Ribosomal protein S9, conserved site Ribosomal_S9_CS Conserved_site
IPR019741 Galactokinase, conserved site Galactokinase_CS Conserved_site
IPR019539 Galactokinase galactose-binding domain GalKase_gal-bd Domain
IPR006203 GHMP kinase, ATP-binding, conserved site GHMP_knse_ATP-bd_CS Conserved_site
IPR020539 Ribonuclease P, conserved site RNase_P_CS Conserved_site

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

18 Found In

DB identifier Name Short Name Type
IPR004540 Translation elongation factor EFG/EF2 Transl_elong_EFG/EF2 Family
IPR006205 Mevalonate kinase Mev_gal_kin Family
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family
IPR001174 Galactokinase/homoserine kinase Galkinase Family
IPR005935 Diphosphomevalonate decarboxylase Mev_diP_decarb Family
IPR000705 Galactokinase Galactokinase Family
IPR006206 Mevalonate/galactokinase Mevalonate/galactokinase Family
IPR005734 DNA topoisomerase VI, subunit B TopoVI_B Family
IPR004543 Translation elongation factor EFG/EF2, archaeal Transl_elong_EFG/EF2_arc Family
IPR005916 Phosphomevalonate kinase, eukaryotic Pmev_kin_euk Family
IPR016005 Phosphomevalonate kinase, ERG8 Pmev_kin_ERG8 Family
IPR005917 Phosphomevalonate kinase, Gram-positive Pmev_kin_Gpos Family
IPR020667 DNA mismatch repair protein, MutL DNA_mismatch_repair_MutL Family
IPR012369 Galactokinase, glycosyltransferase Galk_glycosyltransferase Family
IPR000870 Homoserine kinase Homoserine_kinase Family
IPR014606 D,D-heptose 7-phosphate kinase Heptose_7-P_kinase Family
IPR010189 Shikimate kinase, archaea SK_arc Family
IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase IspE Family

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain

239 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0071766 Q9W237 Drosophila melanogaster
FBpp0086997 Q7K2V9 Drosophila melanogaster
FBpp0075148 Q9VV61 Drosophila melanogaster
FBpp0085265 P13060 Drosophila melanogaster
FBpp0080825 P15348 Drosophila melanogaster
FBpp0087867 A1Z7C1 Drosophila melanogaster
FBpp0081263 Q8SXF0 Drosophila melanogaster
FBpp0073903 Q9VXQ3 Drosophila melanogaster
FBpp0084626 Q9VAX8 Drosophila melanogaster
FBpp0086520 A1ZA03 Drosophila melanogaster
FBpp0110439 Q8SYP9 Drosophila melanogaster
FBpp0076282 Q95U34 Drosophila melanogaster
FBpp0079500 P31009 Drosophila melanogaster
FBpp0079041 Q9VM33 Drosophila melanogaster
FBpp0271918 Q7KUT2 Drosophila melanogaster
FBpp0288333 Q29F49 Drosophila pseudoobscura
FBpp0286762 Q29EI2 Drosophila pseudoobscura
FBpp0277387 Q292K5 Drosophila pseudoobscura
FBpp0287999 Q29K53 Drosophila pseudoobscura
FBpp0277797 Q290H8 Drosophila pseudoobscura
FBpp0272539 B5DSM5 Drosophila pseudoobscura
FBpp0273274 B5DKQ3 Drosophila pseudoobscura
FBpp0273278 B5DKQ5 Drosophila pseudoobscura
FBpp0276263 Q28YP5 Drosophila pseudoobscura
FBpp0277369 B5DZ21 Drosophila pseudoobscura
FBpp0280317 Q29ND6 Drosophila pseudoobscura
FBpp0280351 Q29N77 Drosophila pseudoobscura
FBpp0281172 Q294L5 Drosophila pseudoobscura
FBpp0282698 Q29BD5 Drosophila pseudoobscura
FBpp0285750 B5DK66 Drosophila pseudoobscura