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Protein Domain : IPR014729

Name  Rossmann-like alpha/beta/alpha sandwich fold Short Name  Rossmann-like_a/b/a_fold
Type  Domain Description  This entry represents domains related by a common ancestor that have a Rossmann-like, 3-layer, alpha/beta/alpha sandwich fold. Protein families in which the domain is found include:Nucleotidylyl transferases () such as cytidylyltransferases [], adenylyltransferases [].Class I aminoacyl-tRNA synthetases (catalytic domain), such as tyrosyl-tRNA synthetase () and glutaminyl-tRNA synthetase () [].Pantothenate synthetases () [].ATP sulphurylase (central domain) []N-type ATP pyrophosphatases, such as beta-lactam synthetase () and GMP synthase () [].PP-loop ATPases such as the cell cycle protein MesJ (N-terminal domain) [].Phosphoadenylyl sulphate (PAPS) reductase []Electron transfer flavoprotein (ETFP) subunits, such as the N-terminal domains of the alpha and beta subunits [].Universal stress protein A (UspA) [].Cryptochrome and DNA photolyase [].

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9 Child Features

DB identifier Name Short Name Type
IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase tRNA-lysidine/thiocyt_synth Domain
IPR002500 Phosphoadenosine phosphosulphate reductase PAPS_reduct Domain
IPR001962 Asparagine synthase Asn_synthase Domain
IPR022310 NAD/GMP synthase NAD/GMP_synthase Domain
IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal ETF_a/b_N Domain
IPR024951 Sulphate adenylyltransferase catalytic domain Sulfurylase_cat_dom Domain
IPR020536 Thil, C-terminal domain ThiI_C_dom Domain
IPR003848 Domain of unknown function DUF218 DUF218 Domain
IPR006016 UspA UspA Domain

8 Contains

DB identifier Name Short Name Type
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site aa-tRNA-synth_I_CS Conserved_site
IPR002300 Aminoacyl-tRNA synthetase, class Ia aa-tRNA-synth_Ia Domain
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain Val/Leu/Ile-tRNA-synth_edit Domain
IPR004821 Cytidyltransferase-like domain Cyt_trans-like Domain
IPR020554 Uncharacterised protein family UPF0021, conserved site UPF0021_CS Conserved_site
IPR000049 Electron transfer flavoprotein, beta-subunit, conserved site ET-Flavoprotein_bsu_CS Conserved_site
IPR018223 Argininosuccinate synthase, conserved site Arginosuc_synth_CS Conserved_site
IPR015864 FAD synthetase FAD_synthase Domain

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

52 Found In

DB identifier Name Short Name Type
IPR012089 2-thiocytidine tRNA biosynthesis protein, TtcA 2-thiocytidine_tRNA_synth_TtcA Family
IPR012183 FAD synthetase, molybdopterin binding FAD_synth_Mopterin-bd Family
IPR002303 Valine-tRNA ligase Valyl-tRNA_ligase Family
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic Glu-tRNA-synth_arc/euk Family
IPR000924 Glutamyl/glutaminyl-tRNA synthetase Glu/Gln-tRNA-synth Family
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain Glu/Gln-tRNA-synth_Ib_cat-dom Domain
IPR002305 Aminoacyl-tRNA synthetase, class Ic aa-tRNA-synth_Ic Family
IPR002307 Tyrosine-tRNA ligase Tyr-tRNA-ligase Family
IPR006426 Asparagine synthase, glutamine-hydrolyzing Asn_synth_AEB Family
IPR001278 Arginine-tRNA ligase Arg-tRNA-ligase Family
IPR001674 GMP synthase, C-terminal GMP_synth_C Domain
IPR002306 Tryptophan-tRNA ligase Trp-tRNA-ligase Family
IPR001308 Electron transfer flavoprotein, alpha subunit ETF_a Family
IPR015803 Cysteine-tRNA ligase Cys-tRNA-ligase Family
IPR014445 Glutamine-dependent NAD(+) synthetase Gln-dep_NAD_synthase Family
IPR002302 Leucine-tRNA ligase Leu-tRNA-ligase Family
IPR002761 DUF71 domain DUF71_dom Domain
IPR012255 Electron transfer flavoprotein, beta subunit ETF_b Family
IPR004506 tRNA-specific 2-thiouridylase tRNA-specific_2-thiouridylase Family
IPR002301 Isoleucine-tRNA ligase Ile-tRNA-ligase Family
IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial Glu-tRNA-ligase_bac/mito Family
IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic Leu-tRNA-synth_Ia_arc/euk Family
IPR005248 Probable nicotinate-nucleotide adenylyltransferase NAMN_adtrnsfrase Family
IPR006050 DNA photolyase, N-terminal DNA_photolyase_N Domain
IPR008148 DNA photolyase, class 2 DNA_photolyase_2 Family
IPR002081 Cryptochrome/DNA photolyase, class 1 Cryptochrome/DNA_photolyase_1 Family
IPR001518 Argininosuccinate synthase Arginosuc_synth Family
IPR020791 Leucine-tRNA ligase, archaeal Leu-tRNA-lgase_arc Family
IPR002904 Lysine-tRNA ligase Lys-tRNA-ligase Family
IPR019947 Deoxyribodipyrimidine photo-lyase, 8-HDF type Photolyase_8HDF Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

506 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073676 Q9VYA0 Drosophila melanogaster
FBpp0073965 Q9VXN4 Drosophila melanogaster
FBpp0072625 Q9W0D9 Drosophila melanogaster
FBpp0086847 Q0E993 Drosophila melanogaster
FBpp0073444 Q8MRI4 Drosophila melanogaster
FBpp0075168 Q9VV60 Drosophila melanogaster
FBpp0073204 Q9VZ82 Drosophila melanogaster
FBpp0072334 Q9W107 Drosophila melanogaster
FBpp0082356 Q9VFL5 Drosophila melanogaster
FBpp0086373 Q7KN90 Drosophila melanogaster
FBpp0089009 Q7KTW9 Drosophila melanogaster
FBpp0076826 Q9VRP4 Drosophila melanogaster
FBpp0085809 A1ZBE9 Drosophila melanogaster
FBpp0076287 Q9VSR7 Drosophila melanogaster
FBpp0083898 P28668 Drosophila melanogaster
FBpp0087914 Q7JY97 Drosophila melanogaster
FBpp0087915 A1Z757 Drosophila melanogaster
FBpp0077251 Q9VQR8 Drosophila melanogaster
FBpp0080079 Q9VJY1 Drosophila melanogaster
FBpp0087712 Q7JWW5 Drosophila melanogaster
FBpp0289202 Q5LJP9 Drosophila melanogaster
FBpp0075169 Q9VV59 Drosophila melanogaster
FBpp0080020 Q9VK25 Drosophila melanogaster
FBpp0080022 Q8IP80 Drosophila melanogaster
FBpp0080021 Q8IP79 Drosophila melanogaster
FBpp0074907 Q9VVL8 Drosophila melanogaster
FBpp0080934 Q0E8P0 Drosophila melanogaster
FBpp0081461 Q0KI98 Drosophila melanogaster
FBpp0084902 Q0KHZ6 Drosophila melanogaster
FBpp0073528 Q9VYI5 Drosophila melanogaster