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Protein Domain : IPR008967

Name  p53-like transcription factor, DNA-binding Short Name  p53-like_TF_DNA-bd
Type  Domain Description  This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis []; NFATC regulates the production of effector proteins involved in coordinating the immune response []; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth []; STAT-1 plays an important role in B lymphocyte growth and function []; and NFkappaB is involved in the inflammatory response []. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex []. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability []. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.

Publication Counts Displayer

5 Child Features

DB identifier Name Short Name Type
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain p53/RUNT-type_TF_DNA-bd Domain
IPR013801 STAT transcription factor, DNA-binding STAT_TF_DNA-bd Domain
IPR015351 LAG1, DNA binding LAG1_DNA-bd Domain
IPR024061 NDT80 DNA-binding domain NDT80_DNA-bd_dom Domain
IPR011539 Rel homology domain RHD Domain

2 Contains

DB identifier Name Short Name Type
IPR012345 STAT transcription factor, DNA-binding, subdomain STAT_TF_DNA-bd_sub Domain
IPR018186 Transcription factor, T-box, conserved site TF_T-box_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF49417 SSF IPR008967

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR001699 Transcription factor, T-box TF_T-box Family
IPR002070 Transcription factor, Brachyury TF_Brachyury Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
p53-like transcription factor, DNA-binding   GO:0003700 sequence-specific DNA binding transcription factor activity
p53-like transcription factor, DNA-binding   GO:0006355 regulation of transcription, DNA-templated

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
p53-like transcription factor, DNA-binding   GO:0003700 sequence-specific DNA binding transcription factor activity
p53-like transcription factor, DNA-binding   GO:0006355 regulation of transcription, DNA-templated

0 Parent Features

416 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0083753 Q8IMZ4 Drosophila melanogaster
FBpp0076249 Q9U8L5 Drosophila melanogaster
FBpp0303938 M9PBY6 Drosophila melanogaster
FBpp0078726 Q9VMR2 Drosophila melanogaster
FBpp0290793 P98149 Drosophila melanogaster
FBpp0076248 Q9VST0 Drosophila melanogaster
FBpp0083752 Q9N6D8 Drosophila melanogaster
FBpp0072165 Q9W1A0 Drosophila melanogaster
FBpp0080559 E1JHK3 Drosophila melanogaster
FBpp0080560 P15330 Drosophila melanogaster
FBpp0076971 P22814 Drosophila melanogaster
FBpp0290792 E1JHK2 Drosophila melanogaster
FBpp0071255 Q9W349 Drosophila melanogaster
FBpp0076274 Q9VST2 Drosophila melanogaster
FBpp0301041 M9NEV8 Drosophila melanogaster
FBpp0301040 M9NE80 Drosophila melanogaster
FBpp0070640 E1JJD8 Drosophila melanogaster
FBpp0303589 M9PH16 Drosophila melanogaster
FBpp0080261 P28159 Drosophila melanogaster
FBpp0088375 Q94527 Drosophila melanogaster
FBpp0071187 Q9W3F4 Drosophila melanogaster
FBpp0078710 Q94890 Drosophila melanogaster
FBpp0088489 Q24151 Drosophila melanogaster
FBpp0073639 Q9VYA6 Drosophila melanogaster
FBpp0309342 M9PH25 Drosophila melanogaster
FBpp0304659 Q9VRA9 Drosophila melanogaster
FBpp0111726 Q27J10 Drosophila melanogaster
FBpp0300896 D5AEJ5 Drosophila melanogaster
FBpp0300389 Q0KHQ3 Drosophila melanogaster
FBpp0290665 Q9GU53 Drosophila melanogaster