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Protein Domain : IPR013083

Name  Zinc finger, RING/FYVE/PHD-type Short Name  Znf_RING/FYVE/PHD
Type  Domain Description  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents RING-, PHD-, and FYVE-type zinc finger domains, which share a common dimetal (zinc)-bound alpha/beta structural fold, as well as the non-zinc-containing U-box domain, which is similar to the RING zinc finger only lacking the metal ion-binding residues (U-box associated with multi-ubiquitination).

Publication Counts Displayer

5 Child Features

DB identifier Name Short Name Type
IPR001841 Zinc finger, RING-type Znf_RING Domain
IPR011011 Zinc finger, FYVE/PHD-type Znf_FYVE_PHD Domain
IPR018957 Zinc finger, C3HC4 RING-type Znf_C3HC4_RING-type Domain
IPR003613 U box domain Ubox_domain Domain
IPR022723 RDM domain, Ret finger protein-like RDM_domain_RFPL Domain

3 Contains

DB identifier Name Short Name Type
IPR017907 Zinc finger, RING-type, conserved site Znf_RING_CS Conserved_site
IPR017455 Zinc finger, FYVE-related Znf_FYVE-rel Domain
IPR019786 Zinc finger, PHD-type, conserved site Zinc_finger_PHD-type_CS Conserved_site

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

8 Found In

DB identifier Name Short Name Type
IPR012227 TNF receptor-associated factor TRAF TNF_rcpt--assoc_TRAF Family
IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3 MAT1/Tfb3 Family
IPR001237 43kDa postsynaptic protein Postsynaptic Family
IPR002853 Transcription factor TFIIE, alpha subunit TFIIE_asu Family
IPR016818 Nitric oxide synthase-interacting Nitric_oxide_synth-interacting Family
IPR004580 DNA repair protein, Rad18 Rad18 Family
IPR016398 E3 ubiquitin-protein ligase p28 E3_ubiquitin-prot_ligase_p28 Family
IPR017335 E3 ubiquitin ligase, RNF8 E3_Ub_ligase_RNF8 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

2856 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073674 Q9VY98 Drosophila melanogaster
FBpp0293057 M9MRI4 Drosophila melanogaster
FBpp0079685 Q86P21 Drosophila melanogaster
FBpp0305727 Q9W5W9 Drosophila melanogaster
FBpp0078775 Q9VML2 Drosophila melanogaster
FBpp0073753 Q9VY20 Drosophila melanogaster
FBpp0081130 Q7KSZ0 Drosophila melanogaster
FBpp0070458 Q9W4W4 Drosophila melanogaster
FBpp0082409 P20659 Drosophila melanogaster
FBpp0305805 Q9VZY3 Drosophila melanogaster
FBpp0305807 M9PE32 Drosophila melanogaster
FBpp0305804 M9PDV6 Drosophila melanogaster
FBpp0074688 O97159 Drosophila melanogaster
FBpp0304462 M9PIA6 Drosophila melanogaster
FBpp0099808 Q59E34 Drosophila melanogaster
FBpp0075181 Q9VV48 Drosophila melanogaster
FBpp0072702 Q9W0C3 Drosophila melanogaster
FBpp0086906 P25172 Drosophila melanogaster
FBpp0072976 Q9VZU7 Drosophila melanogaster
FBpp0088523 O96838 Drosophila melanogaster
FBpp0071262 Q9W352 Drosophila melanogaster
FBpp0292089 M9MS35 Drosophila melanogaster
FBpp0075510 Q9VUB5 Drosophila melanogaster
FBpp0080686 Q9VJ14 Drosophila melanogaster
FBpp0074385 Q9VWS0 Drosophila melanogaster
FBpp0075275 Q9VUX2 Drosophila melanogaster
FBpp0294022 Q86B79 Drosophila melanogaster
FBpp0070506 Q9W4S2 Drosophila melanogaster
FBpp0302614 M9PDP1 Drosophila melanogaster
FBpp0078288 Q8I0J6 Drosophila melanogaster