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Protein Domain : IPR008974

Name	TRAF-like	Short Name	TRAF-like
Type	Domain	Description	The tumour necrosis factor receptor (TNFR) associated factors (TRAFs) act as signal transducers for both TNFRs and interleukin-1/Toll-like receptors. TRAFs function in immunity, embryonic development, stress response and bone metabolism through their induction of cell proliferation, differentiation, and apoptosis []. TRAFs are characterised by two domains: an N-terminal domain containing RING and zinc finger motifs that is essential for the activation of downstream effectors, and a C-terminal TRAF domain that is essential for self-association and receptor interaction []. The TRAF-domain like fold is a beta-sandwich consisting of 8 strands in 2 beta sheets and has a circularly permuted greek-key immunoglobulin-fold topology that contains an extra strand.The substrate-binding domain (SBD) of the SIAH (seven in absentia homolog) family of proteins is structurally highly similar to the TRAF domain. The SIAH SBD interacts with a number of proteins, and is involved in TNF-alpha-mediated NFkappaB activation [].

Publication Counts Displayer

2 Child Features

DB identifier	Name	Short Name	Type
IPR002083	MATH	MATH	Domain
IPR018121	Seven-in-absentia protein, TRAF-like domain	7-in-absentia-prot_TRAF-dom	Domain

3 Contains

DB identifier	Name	Short Name	Type
IPR013323	SIAH-type domain	SIAH-type	Domain
IPR013010	Zinc finger, SIAH-type	Znf_SIAH	Domain
IPR001293	Zinc finger, TRAF-type	Znf_TRAF	Domain

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
SSF49599	SSF	IPR008974

3 Data Sets

Name	URL
Swiss-Prot data set	http://ca.expasy.org/sprot
InterPro data set
InterPro GO Annotation data set

1 Found In

DB identifier	Name	Short Name	Type
IPR004162	E3 ubiquitin-protein ligase SINA like	SINA_like	Family

1 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	TRAF-like		GO:0005515	protein binding

1 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	TRAF-like		GO:0005515	protein binding

0 Parent Features

477 Proteins

DB identifier	Primary Accession	Organism . Name
FBpp0070458	Q9W4W4	Drosophila melanogaster
FBpp0073474	Q9VYQ8	Drosophila melanogaster
FBpp0075091	P21461	Drosophila melanogaster
FBpp0072874	Q9VZV5	Drosophila melanogaster
FBpp0080156	Q9VJW5	Drosophila melanogaster
FBpp0290846	C7LAF6	Drosophila melanogaster
FBpp0071136	Q9W3I9	Drosophila melanogaster
FBpp0099767	Q9VFP2	Drosophila melanogaster
FBpp0074051	Q8IR14	Drosophila melanogaster
FBpp0074050	Q9VXG5	Drosophila melanogaster
FBpp0074049	Q960H6	Drosophila melanogaster
FBpp0077119	Q9XYR0	Drosophila melanogaster
FBpp0290897	Q8T3Y0	Drosophila melanogaster
FBpp0075265	Q9VUV7	Drosophila melanogaster
FBpp0306504	A8DYU9	Drosophila melanogaster
FBpp0283924	Q298W3	Drosophila pseudoobscura
FBpp0291895	I5ANU6	Drosophila pseudoobscura
FBpp0291894	I5ANU5	Drosophila pseudoobscura
FBpp0275034	Q2M0J1	Drosophila pseudoobscura
FBpp0286472	Q29HR3	Drosophila pseudoobscura
FBpp0275155	B5DPK4	Drosophila pseudoobscura
FBpp0274243	Q29GI2	Drosophila pseudoobscura
FBpp0279066	B5DHC1	Drosophila pseudoobscura
FBpp0279320	Q29PB4	Drosophila pseudoobscura
FBpp0279527	Q29LI9	Drosophila pseudoobscura
FBpp0282681	Q29HD1	Drosophila pseudoobscura
FBpp0283353	Q29HL8	Drosophila pseudoobscura
FBpp0286277	Q29E32	Drosophila pseudoobscura
FBpp0286932	Q29DV1	Drosophila pseudoobscura
FBpp0286933	Q29DV0	Drosophila pseudoobscura

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