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Protein Domain : IPR002083

Name  MATH Short Name  MATH
Type  Domain Description  Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a conserved region of about 180 residues, the meprin and TRAF homology (MATH) domain []. Meprins are mammalian tissue-specific metalloendopeptidases of the astacin family implicated in developmental, normal and pathological processes by hydrolysing a variety of proteins. Various growth factors, cytokines, and extracellular matrix proteins are substrates for meprins. They are composed of five structural domains: an N-terminal endopeptidase domain, a MAM domain (see), a MATH domain, an EGF-like domain (see ) and a C-terminal transmembrane region. Meprin A and B form membrane bound homotetramer whereas homooligomers of meprin A are secreted. A proteolitic site adjacent to the MATH domain, only present in meprin A, allows the release of the protein from the membrane [].TRAF proteins were first isolated by their ability to interact with TNF receptors []. They promote cell survival by the activation of downstream protein kinases and, finally, transcription factors of the NF-kB and AP-1 family. The TRAF proteins are composed of 3 structural domains: a RING finger (see ) in the N-terminal part of the protein, one to seven TRAF zinc fingers (see ) in the middle and the MATH domain in the C-terminal part []. The MATH domain is necessary and sufficient for self-association and receptor interaction. From the structural analysis two consensus sequence recognised by the TRAF domain havebeen defined: a major one, [PSAT]x[QE]E and a minor one, PxQxxD [].The structure of the TRAF2 protein reveals a trimeric self-association of the MATH domain []. The domain forms a new, light-stranded antiparallel beta sandwich structure. A coiled-coil region adjacent to the MATH domain is also important for the trimerisation. The oligomerisation is essential for establishing appropriate connections to form signalling complexes with TNF receptor-1. The ligand binding surface of TRAF proteins is located in beta-strands 6 and 7 [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00917 PFAM IPR002083
PS50144 PROFILE IPR002083
SM00061 SMART IPR002083

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR012227 TNF receptor-associated factor TRAF TNF_rcpt--assoc_TRAF Family
IPR008294 Meprin alpha/beta subunit Meprin Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
MATH   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
MATH   GO:0005515 protein binding

1 Parent Features

DB identifier Name Short Name Type
IPR008974 TRAF-like TRAF-like Domain

436 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073474 Q9VYQ8 Drosophila melanogaster
FBpp0290846 C7LAF6 Drosophila melanogaster
FBpp0071136 Q9W3I9 Drosophila melanogaster
FBpp0099767 Q9VFP2 Drosophila melanogaster
FBpp0074051 Q8IR14 Drosophila melanogaster
FBpp0074050 Q9VXG5 Drosophila melanogaster
FBpp0074049 Q960H6 Drosophila melanogaster
FBpp0077119 Q9XYR0 Drosophila melanogaster
FBpp0306504 A8DYU9 Drosophila melanogaster
FBpp0283924 Q298W3 Drosophila pseudoobscura
FBpp0291895 I5ANU6 Drosophila pseudoobscura
FBpp0291894 I5ANU5 Drosophila pseudoobscura
FBpp0274243 Q29GI2 Drosophila pseudoobscura
FBpp0279527 Q29LI9 Drosophila pseudoobscura
FBpp0282681 Q29HD1 Drosophila pseudoobscura
FBpp0283353 Q29HL8 Drosophila pseudoobscura
FBpp0160004 B4KC14 Drosophila mojavensis
FBpp0163627 B4L8G7 Drosophila mojavensis
FBpp0163680 B4L8S0 Drosophila mojavensis
FBpp0170699 B4L5P2 Drosophila mojavensis
FBpp0171257 B4KES9 Drosophila mojavensis
FBpp0228802 B4MB81 Drosophila virilis
FBpp0230538 B4MDS3 Drosophila virilis
FBpp0232930 B4MG84 Drosophila virilis
FBpp0233175 B4M202 Drosophila virilis
FBpp0233214 B4M1S0 Drosophila virilis
FBpp0261736 B4PY90 Drosophila yakuba
FBpp0262282 B4PXT2 Drosophila yakuba
FBpp0262485 B4Q0E8 Drosophila yakuba
FBpp0263293 B4NYJ2 Drosophila yakuba