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Protein Domain : IPR011333

Name  BTB/POZ fold Short Name  BTB/POZ_fold
Type  Domain Description  The BTB (for BR-C, ttk and bab) []or POZ (for Pox virus and Zinc finger) [, ]domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination []. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets []. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [, , ]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.This entry differs from IPR000210 in including POZ-containing Skp1 proteins.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR000210 BTB/POZ-like BTB/POZ-like Domain

1 Contains

DB identifier Name Short Name Type
IPR016073 SKP1 component, POZ domain Skp1_comp_POZ Domain

2 Cross References

Source . Name

Subject . Primary Identifier
G3DSA:3.30.710.10 GENE3D IPR011333
SSF54695 SSF IPR011333

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

9 Found In

DB identifier Name Short Name Type
IPR016897 E3 ubiquitin ligase, SCF complex, Skp subunit E3_ubiquit_lig_SCF_Skp Family
IPR001232 SKP1 component Skp1_comp Family
IPR003972 Potassium channel, voltage dependent, Kv1 K_chnl_volt-dep_Kv1 Family
IPR020467 Potassium channel, voltage dependent, Kv1.4 K_chnl_volt-dep_Kv1.4 Family
IPR004048 Potassium channel, voltage dependent, Kv1.1 K_chnl_volt-dep_Kv1.1 Family
IPR004350 Potassium channel, voltage dependent, Kv2.1 K_chnl_volt-dep_Kv2.1 Family
IPR004050 Potassium channel, voltage dependent, Kv1.3 K_chnl_volt-dep_Kv1.3 Family
IPR005404 Potassium channel, voltage dependent, Kv3.3 K_chnl_volt-dep_Kv3.3 Family
IPR004049 Potassium channel, voltage dependent, Kv1.2 K_chnl_volt-dep_Kv1.2 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

2193 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0071426 Q9W2S3 Drosophila melanogaster
FBpp0305260 M9PFM7 Drosophila melanogaster
FBpp0099866 A4V1Y7 Drosophila melanogaster
FBpp0089417 A4V1Y6 Drosophila melanogaster
FBpp0305259 Q2PDY1 Drosophila melanogaster
FBpp0099867 Q2PDY2 Drosophila melanogaster
FBpp0072382 Q0E8K5 Drosophila melanogaster
FBpp0307379 H1UUK0 Drosophila melanogaster
FBpp0307384 Q9VY72 Drosophila melanogaster
FBpp0307381 M9NEG1 Drosophila melanogaster
FBpp0307382 M9PJM9 Drosophila melanogaster
FBpp0085430 Q7JZ62 Drosophila melanogaster
FBpp0305171 Q7K187 Drosophila melanogaster
FBpp0070791 Q7YZ93 Drosophila melanogaster
FBpp0070790 Q9W458 Drosophila melanogaster
FBpp0075887 Q9VTJ5 Drosophila melanogaster
FBpp0305467 M9PDT5 Drosophila melanogaster
FBpp0305466 M9PE50 Drosophila melanogaster
FBpp0072538 Q9W0K7 Drosophila melanogaster
FBpp0305468 M9PGP8 Drosophila melanogaster
FBpp0300865 D5SHR0 Drosophila melanogaster
FBpp0071609 Q9W2F9 Drosophila melanogaster
FBpp0073518 Q9VYJ8 Drosophila melanogaster
FBpp0288661 B9A0N7 Drosophila melanogaster
FBpp0077004 Q9VRA7 Drosophila melanogaster
FBpp0073935 Q9VXL5 Drosophila melanogaster
FBpp0083063 Q8IN81 Drosophila melanogaster
FBpp0070252 M9MSM6 Drosophila melanogaster
FBpp0070251 Q24206 Drosophila melanogaster
FBpp0070256 D8FT05 Drosophila melanogaster